DICP OpenIR
Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery
Wang, Yanfang1,2; Wang, Beibei1,2; Liao, Han1,2; Song, Xiaojie1,2; Wu, Hao1,2; Wang, Huihui1,2; Shen, Hujun3; Ma, Xiaojun1; Tan, Mingqian1,4
刊名JOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c5tb01197c
3期:36页:7291-7299
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]COARSE-GRAINED MODEL ; ELECTRIC MULTIPOLE POTENTIALS ; MOLECULAR-DYNAMICS ; GAY-BERNE ; OXIDATIVE STRESS ; SIMULATIONS ; DOXORUBICIN ; RELEASE ; LIQUIDS ; NANOPARTICLES
英文摘要Mitochondrial dysfunctions cause numerous human disorders and the development of mitochondria-targeted nanocarriers for drug delivery has aroused great attention. Herein, we report the synthesis of a liposomal nanohybrid cerasome modified with triphosphonium (TPP) for drug delivery to the mitochondrial matrix. The cerasomes were observed to possess an average size of about 38 nm in diameter, and the theoretical simulation of GBEMP mapping demonstrated that the amphiphilic organotrialkoxysilanes were stable as a bilayer equilibrium conformation after self-assembly. The cerasomes showed good stability, excellent biocompatibility and sustainable drug release behavior. Moreover, the TPP-targeted cerasomes resulted in greater drug accumulation in mitochondria, thus leading to a greater antitumor effect as compared to non-targeted cerasomes by using doxorubicin as a modal drug. The specific accumulation of TPP-targeted cerasomes within mitochondria was also confirmed by using JC-1 as the fluorescent probe to analyze the mitochondrial transmembrane potential change.
语种英语
WOS记录号WOS:000360658000016
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146504
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China
4.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yanfang,Wang, Beibei,Liao, Han,et al. Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(36):7291-7299.
APA Wang, Yanfang.,Wang, Beibei.,Liao, Han.,Song, Xiaojie.,Wu, Hao.,...&Tan, Mingqian.(2015).Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery.JOURNAL OF MATERIALS CHEMISTRY B,3(36),7291-7299.
MLA Wang, Yanfang,et al."Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery".JOURNAL OF MATERIALS CHEMISTRY B 3.36(2015):7291-7299.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yanfang]的文章
[Wang, Beibei]的文章
[Liao, Han]的文章
百度学术
百度学术中相似的文章
[Wang, Yanfang]的文章
[Wang, Beibei]的文章
[Liao, Han]的文章
必应学术
必应学术中相似的文章
[Wang, Yanfang]的文章
[Wang, Beibei]的文章
[Liao, Han]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。