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题名: Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery
作者: Wang, Yanfang1, 2;  Wang, Beibei1, 2;  Liao, Han1, 2;  Song, Xiaojie1, 2;  Wu, Hao1, 2;  Wang, Huihui1, 2;  Shen, Hujun3;  Ma, Xiaojun1;  Tan, Mingqian1, 4
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c5tb01197c
卷: 3, 期:36, 页:7291-7299
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Mitochondrial dysfunctions cause numerous human disorders and the development of mitochondria-targeted nanocarriers for drug delivery has aroused great attention. Herein, we report the synthesis of a liposomal nanohybrid cerasome modified with triphosphonium (TPP) for drug delivery to the mitochondrial matrix. The cerasomes were observed to possess an average size of about 38 nm in diameter, and the theoretical simulation of GBEMP mapping demonstrated that the amphiphilic organotrialkoxysilanes were stable as a bilayer equilibrium conformation after self-assembly. The cerasomes showed good stability, excellent biocompatibility and sustainable drug release behavior. Moreover, the TPP-targeted cerasomes resulted in greater drug accumulation in mitochondria, thus leading to a greater antitumor effect as compared to non-targeted cerasomes by using doxorubicin as a modal drug. The specific accumulation of TPP-targeted cerasomes within mitochondria was also confirmed by using JC-1 as the fluorescent probe to analyze the mitochondrial transmembrane potential change.
关键词[WOS]: COARSE-GRAINED MODEL ;  ELECTRIC MULTIPOLE POTENTIALS ;  MOLECULAR-DYNAMICS ;  GAY-BERNE ;  OXIDATIVE STRESS ;  SIMULATIONS ;  DOXORUBICIN ;  RELEASE ;  LIQUIDS ;  NANOPARTICLES
语种: 英语
WOS记录号: WOS:000360658000016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146504
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China
4.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China

Recommended Citation:
Wang, Yanfang,Wang, Beibei,Liao, Han,et al. Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(36):7291-7299.
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