DICP OpenIR
Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery
Wang, Yanfang1,2; Wang, Beibei1,2; Liao, Han1,2; Song, Xiaojie1,2; Wu, Hao1,2; Wang, Huihui1,2; Shen, Hujun3; Ma, Xiaojun1; Tan, Mingqian1,4
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c5tb01197c
Volume3Issue:36Pages:7291-7299
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectMaterials Science, Biomaterials
WOS Research AreaMaterials Science
WOS KeywordCOARSE-GRAINED MODEL ; ELECTRIC MULTIPOLE POTENTIALS ; MOLECULAR-DYNAMICS ; GAY-BERNE ; OXIDATIVE STRESS ; SIMULATIONS ; DOXORUBICIN ; RELEASE ; LIQUIDS ; NANOPARTICLES
AbstractMitochondrial dysfunctions cause numerous human disorders and the development of mitochondria-targeted nanocarriers for drug delivery has aroused great attention. Herein, we report the synthesis of a liposomal nanohybrid cerasome modified with triphosphonium (TPP) for drug delivery to the mitochondrial matrix. The cerasomes were observed to possess an average size of about 38 nm in diameter, and the theoretical simulation of GBEMP mapping demonstrated that the amphiphilic organotrialkoxysilanes were stable as a bilayer equilibrium conformation after self-assembly. The cerasomes showed good stability, excellent biocompatibility and sustainable drug release behavior. Moreover, the TPP-targeted cerasomes resulted in greater drug accumulation in mitochondria, thus leading to a greater antitumor effect as compared to non-targeted cerasomes by using doxorubicin as a modal drug. The specific accumulation of TPP-targeted cerasomes within mitochondria was also confirmed by using JC-1 as the fluorescent probe to analyze the mitochondrial transmembrane potential change.
Language英语
WOS IDWOS:000360658000016
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146504
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China
4.Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yanfang,Wang, Beibei,Liao, Han,et al. Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(36):7291-7299.
APA Wang, Yanfang.,Wang, Beibei.,Liao, Han.,Song, Xiaojie.,Wu, Hao.,...&Tan, Mingqian.(2015).Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery.JOURNAL OF MATERIALS CHEMISTRY B,3(36),7291-7299.
MLA Wang, Yanfang,et al."Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery".JOURNAL OF MATERIALS CHEMISTRY B 3.36(2015):7291-7299.
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