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Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase
Zhao, Xi-Run1; Huo, Xiao-Kui1; Dong, Pei-Pei2,3; Wang, Chao1; Huang, Shan-Shan1; Zhang, Bao-Jing1; Zhang, Hou-Li1; Deng, Sa1; Liu, Ke-Xin1; Ma, Xiao-Chi1,2
Source PublicationJOURNAL OF NATURAL PRODUCTS
2015-08-01
DOI10.1021/acs.jnatprod.5b00132
Volume78Issue:8Pages:1868-1876
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordFRUITING BODIES ; FR KARST ; INTESTINAL-ABSORPTION ; C-30 TERPENOIDS ; BITTER C-27 ; IN-VITRO ; ACID-F ; TRITERPENOIDS ; CELLS ; POLYSACCHARIDES
AbstractTwelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of Ganoderma lucidum. The new compounds were lanostane nortriterpenoids with 27 carbons (1-5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpenoids (9-12) based on multiple spectroscopic data analysis, including HRESIMS, 1D-NMR, 2D-NMR, and CD. Compounds 1-5 were identified as rare nor-lanostanoids that contain a 17 beta-pentatomic lactone ring. Compound 13, possessing a lactone ring, had been isolated previously. The P-glycoprotein (P-gp) inhibitory effects of compounds 1-21 were evaluated at a concentration of 20 mu M using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR). Compounds 1, 5, 18, and 20 and verapamil increased the accumulation of ADM in MCF-7/ADR cells approximately 3-fold when compared with the negative control. These data support the significant P-glycoprotein inhibitory activities of compounds 1, 5, 18, and 20. In silico docking analysis suggested these compounds had similar P-gp recognition mechanisms compared with those of verapamil (a classical inhibitor). Furthermore, in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against alpha-glucosidase compared with those of the positive control acarbose.
Language英语
WOS IDWOS:000360773700009
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146511
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian 116044, Peoples R China
2.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Xi-Run,Huo, Xiao-Kui,Dong, Pei-Pei,et al. Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1868-1876.
APA Zhao, Xi-Run.,Huo, Xiao-Kui.,Dong, Pei-Pei.,Wang, Chao.,Huang, Shan-Shan.,...&Ma, Xiao-Chi.(2015).Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase.JOURNAL OF NATURAL PRODUCTS,78(8),1868-1876.
MLA Zhao, Xi-Run,et al."Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1868-1876.
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