DICP OpenIR
Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase
Zhao, Xi-Run1; Huo, Xiao-Kui1; Dong, Pei-Pei2,3; Wang, Chao1; Huang, Shan-Shan1; Zhang, Bao-Jing1; Zhang, Hou-Li1; Deng, Sa1; Liu, Ke-Xin1; Ma, Xiao-Chi1,2
刊名JOURNAL OF NATURAL PRODUCTS
2015-08-01
DOI10.1021/acs.jnatprod.5b00132
78期:8页:1868-1876
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]FRUITING BODIES ; FR KARST ; INTESTINAL-ABSORPTION ; C-30 TERPENOIDS ; BITTER C-27 ; IN-VITRO ; ACID-F ; TRITERPENOIDS ; CELLS ; POLYSACCHARIDES
英文摘要Twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of Ganoderma lucidum. The new compounds were lanostane nortriterpenoids with 27 carbons (1-5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpenoids (9-12) based on multiple spectroscopic data analysis, including HRESIMS, 1D-NMR, 2D-NMR, and CD. Compounds 1-5 were identified as rare nor-lanostanoids that contain a 17 beta-pentatomic lactone ring. Compound 13, possessing a lactone ring, had been isolated previously. The P-glycoprotein (P-gp) inhibitory effects of compounds 1-21 were evaluated at a concentration of 20 mu M using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR). Compounds 1, 5, 18, and 20 and verapamil increased the accumulation of ADM in MCF-7/ADR cells approximately 3-fold when compared with the negative control. These data support the significant P-glycoprotein inhibitory activities of compounds 1, 5, 18, and 20. In silico docking analysis suggested these compounds had similar P-gp recognition mechanisms compared with those of verapamil (a classical inhibitor). Furthermore, in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against alpha-glucosidase compared with those of the positive control acarbose.
语种英语
WOS记录号WOS:000360773700009
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146511
专题中国科学院大连化学物理研究所
作者单位1.Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian 116044, Peoples R China
2.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xi-Run,Huo, Xiao-Kui,Dong, Pei-Pei,et al. Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1868-1876.
APA Zhao, Xi-Run.,Huo, Xiao-Kui.,Dong, Pei-Pei.,Wang, Chao.,Huang, Shan-Shan.,...&Ma, Xiao-Chi.(2015).Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase.JOURNAL OF NATURAL PRODUCTS,78(8),1868-1876.
MLA Zhao, Xi-Run,et al."Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1868-1876.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Xi-Run]的文章
[Huo, Xiao-Kui]的文章
[Dong, Pei-Pei]的文章
百度学术
百度学术中相似的文章
[Zhao, Xi-Run]的文章
[Huo, Xiao-Kui]的文章
[Dong, Pei-Pei]的文章
必应学术
必应学术中相似的文章
[Zhao, Xi-Run]的文章
[Huo, Xiao-Kui]的文章
[Dong, Pei-Pei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。