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题名: Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase
作者: Zhao, Xi-Run1;  Huo, Xiao-Kui1;  Dong, Pei-Pei2, 3;  Wang, Chao1;  Huang, Shan-Shan1;  Zhang, Bao-Jing1;  Zhang, Hou-Li1;  Deng, Sa1;  Liu, Ke-Xin1;  Ma, Xiao-Chi1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2015-08-01
DOI: 10.1021/acs.jnatprod.5b00132
卷: 78, 期:8, 页:1868-1876
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of Ganoderma lucidum. The new compounds were lanostane nortriterpenoids with 27 carbons (1-5 and 8), lanostane nor-triterpenoids with 25 carbons (6 and 7), and lanostane triterpenoids (9-12) based on multiple spectroscopic data analysis, including HRESIMS, 1D-NMR, 2D-NMR, and CD. Compounds 1-5 were identified as rare nor-lanostanoids that contain a 17 beta-pentatomic lactone ring. Compound 13, possessing a lactone ring, had been isolated previously. The P-glycoprotein (P-gp) inhibitory effects of compounds 1-21 were evaluated at a concentration of 20 mu M using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR). Compounds 1, 5, 18, and 20 and verapamil increased the accumulation of ADM in MCF-7/ADR cells approximately 3-fold when compared with the negative control. These data support the significant P-glycoprotein inhibitory activities of compounds 1, 5, 18, and 20. In silico docking analysis suggested these compounds had similar P-gp recognition mechanisms compared with those of verapamil (a classical inhibitor). Furthermore, in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against alpha-glucosidase compared with those of the positive control acarbose.
关键词[WOS]: FRUITING BODIES ;  FR KARST ;  INTESTINAL-ABSORPTION ;  C-30 TERPENOIDS ;  BITTER C-27 ;  IN-VITRO ;  ACID-F ;  TRITERPENOIDS ;  CELLS ;  POLYSACCHARIDES
语种: 英语
WOS记录号: WOS:000360773700009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146511
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Coll Pharm, Key Lab Metab & Transport Liaoning, Dalian 116044, Peoples R China
2.Dalian Med Univ, Acad Integrat Med, Dalian 116044, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Zhao, Xi-Run,Huo, Xiao-Kui,Dong, Pei-Pei,et al. Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and alpha-Glucosidase[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1868-1876.
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