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题名: Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme
作者: Li, Yinghao1, 2;  Cheng, Mingpan1, 2;  Hao, Jingya1, 2;  Wang, Changhao1;  Jia, Guoqing1;  Li, Can1
刊名: CHEMICAL SCIENCE
发表日期: 2015
DOI: 10.1039/c5sc01381j
卷: 6, 期:10, 页:5578-5585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The cofactors commonly involved in natural enzymes have provided the inspiration for numerous advances in the creation of artificial metalloenzymes. Nevertheless, to design an appropriate cofactor for a given biomolecular scaffold or vice versa remains a challenge in developing efficient catalysts in biochemistry. Herein, we extend the idea of G-quadruplex-targeting anticancer drug design to construct a G-quadruplex DNA metalloenzyme. We found that a series of terpyridine-Cu(II) complexes (CuLn) can serve as excellent cofactors to dock with human telemetric G-quadruplex DNA. The resulting G-quadruplex DNA metalloenzyme utilising CuL1 catalyzes an enantioselective Diels-Alder reaction with enantioselectivity of >99% enantiomeric excess and about 73-fold rate acceleration compared to CuL1 alone. The terpyridine-Cu(II) complex cofactors demonstrate dual functions, both as an active site to perform catalysis and as a structural regulator to promote the folding of human telemetric G-quadruplex DNA towards excellent catalysts.
关键词[WOS]: DIELS-ALDER REACTION ;  ASYMMETRIC CATALYSIS ;  ARTIFICIAL METALLOENZYMES ;  ENANTIOSELECTIVE CATALYSIS ;  CIRCULAR-DICHROISM ;  HYBRID CATALYSTS ;  SMALL MOLECULES ;  CD SPECTRA ;  ORDER DNA ;  COMPLEXES
语种: 英语
WOS记录号: WOS:000361212000027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146517
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Li, Yinghao,Cheng, Mingpan,Hao, Jingya,et al. Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme[J]. CHEMICAL SCIENCE,2015,6(10):5578-5585.
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