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Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme
Li, Yinghao1,2; Cheng, Mingpan1,2; Hao, Jingya1,2; Wang, Changhao1; Jia, Guoqing1; Li, Can1
刊名CHEMICAL SCIENCE
2015
DOI10.1039/c5sc01381j
6期:10页:5578-5585
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DIELS-ALDER REACTION ; ASYMMETRIC CATALYSIS ; ARTIFICIAL METALLOENZYMES ; ENANTIOSELECTIVE CATALYSIS ; CIRCULAR-DICHROISM ; HYBRID CATALYSTS ; SMALL MOLECULES ; CD SPECTRA ; ORDER DNA ; COMPLEXES
英文摘要The cofactors commonly involved in natural enzymes have provided the inspiration for numerous advances in the creation of artificial metalloenzymes. Nevertheless, to design an appropriate cofactor for a given biomolecular scaffold or vice versa remains a challenge in developing efficient catalysts in biochemistry. Herein, we extend the idea of G-quadruplex-targeting anticancer drug design to construct a G-quadruplex DNA metalloenzyme. We found that a series of terpyridine-Cu(II) complexes (CuLn) can serve as excellent cofactors to dock with human telemetric G-quadruplex DNA. The resulting G-quadruplex DNA metalloenzyme utilising CuL1 catalyzes an enantioselective Diels-Alder reaction with enantioselectivity of >99% enantiomeric excess and about 73-fold rate acceleration compared to CuL1 alone. The terpyridine-Cu(II) complex cofactors demonstrate dual functions, both as an active site to perform catalysis and as a structural regulator to promote the folding of human telemetric G-quadruplex DNA towards excellent catalysts.
语种英语
WOS记录号WOS:000361212000027
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146517
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Li, Yinghao,Cheng, Mingpan,Hao, Jingya,et al. Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme[J]. CHEMICAL SCIENCE,2015,6(10):5578-5585.
APA Li, Yinghao,Cheng, Mingpan,Hao, Jingya,Wang, Changhao,Jia, Guoqing,&Li, Can.(2015).Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme.CHEMICAL SCIENCE,6(10),5578-5585.
MLA Li, Yinghao,et al."Terpyridine-Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme".CHEMICAL SCIENCE 6.10(2015):5578-5585.
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