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题名: Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells
作者: Wang, Jun-Zhi1;  Yan, Xi-Ming1;  Li, Zi-Cheng2;  Luo, Hua-Jun1;  Huang, Nian-Yu1;  Deng, Wei-Qiao1, 3
关键词: Bisabolangelone ;  Calcium channel ;  Neurons ;  Molecular docking
刊名: MEDICINAL CHEMISTRY RESEARCH
发表日期: 2015-11-01
DOI: 10.1007/s00044-015-1421-x
卷: 24, 期:11, 页:3813-3820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Bisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.
关键词[WOS]: CALCIUM-CHANNELS ;  PARKINSONS ;  DISEASE
语种: 英语
WOS记录号: WOS:000361758000005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146560
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China
2.China Three Gorges Univ, Coll Med, Yichang 443002, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,et al. Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells[J]. MEDICINAL CHEMISTRY RESEARCH,2015,24(11):3813-3820.
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