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Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells
Wang, Jun-Zhi1; Yan, Xi-Ming1; Li, Zi-Cheng2; Luo, Hua-Jun1; Huang, Nian-Yu1; Deng, Wei-Qiao1,3
关键词Bisabolangelone Calcium Channel Neurons Molecular Docking
刊名MEDICINAL CHEMISTRY RESEARCH
2015-11-01
DOI10.1007/s00044-015-1421-x
24期:11页:3813-3820
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CALCIUM-CHANNELS ; PARKINSONS ; DISEASE
英文摘要Bisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.
语种英语
WOS记录号WOS:000361758000005
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146560
专题中国科学院大连化学物理研究所
作者单位1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China
2.China Three Gorges Univ, Coll Med, Yichang 443002, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
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Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,et al. Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells[J]. MEDICINAL CHEMISTRY RESEARCH,2015,24(11):3813-3820.
APA Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,Luo, Hua-Jun,Huang, Nian-Yu,&Deng, Wei-Qiao.(2015).Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells.MEDICINAL CHEMISTRY RESEARCH,24(11),3813-3820.
MLA Wang, Jun-Zhi,et al."Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells".MEDICINAL CHEMISTRY RESEARCH 24.11(2015):3813-3820.
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