DICP OpenIR
Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells
Wang, Jun-Zhi1; Yan, Xi-Ming1; Li, Zi-Cheng2; Luo, Hua-Jun1; Huang, Nian-Yu1; Deng, Wei-Qiao1,3
KeywordBisabolangelone Calcium Channel Neurons Molecular Docking
Source PublicationMEDICINAL CHEMISTRY RESEARCH
2015-11-01
DOI10.1007/s00044-015-1421-x
Volume24Issue:11Pages:3813-3820
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectChemistry, Medicinal
WOS Research AreaPharmacology & Pharmacy
WOS KeywordCALCIUM-CHANNELS ; PARKINSONS ; DISEASE
AbstractBisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.
Language英语
WOS IDWOS:000361758000005
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146560
Collection中国科学院大连化学物理研究所
Affiliation1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China
2.China Three Gorges Univ, Coll Med, Yichang 443002, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,et al. Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells[J]. MEDICINAL CHEMISTRY RESEARCH,2015,24(11):3813-3820.
APA Wang, Jun-Zhi,Yan, Xi-Ming,Li, Zi-Cheng,Luo, Hua-Jun,Huang, Nian-Yu,&Deng, Wei-Qiao.(2015).Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells.MEDICINAL CHEMISTRY RESEARCH,24(11),3813-3820.
MLA Wang, Jun-Zhi,et al."Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells".MEDICINAL CHEMISTRY RESEARCH 24.11(2015):3813-3820.
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