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Tumor cell responses to carbon dots derived from chondroitin sulfate
Wang, Shu-Jun1,2; Wang, Bei-Bei2,3; Bai, Feng-Wu1,4; Ma, Xiao-Jun2
刊名RSC ADVANCES
2015
DOI10.1039/c5ra14585f
5期:99页:81388-81394
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]GRAPHENE QUANTUM DOTS ; MATRIX METALLOPROTEINASES ; DRUG-DELIVERY ; GREEN SYNTHESIS ; CANCER-CELLS ; GROWTH ; INVASION ; METASTASIS ; NANODOTS ; PHOTOLUMINESCENCE
英文摘要Mass production of carbon dots (CDs) derived from chondroitin sulfate (CS) was developed by the facile hydrothermal approach for the first time. The CS derived CDs (CSCDs) possessed good dispersibility and water solubility, bright blue and green luminescence, and relative pH- and photo-stable properties. Moreover, the multicolor CSCDs could be efficiently uptaken by SAS cells and exhibited low cytotoxicity. Therefore, the responses of human oral squamous cell carcinoma SAS cells to CSCDs were further investigated by evaluating their proliferation and invasion. Compared to CS, CSCDs not only provided higher efficiency for proliferation of SAS cells, and up-regulated expression of matrix metalloproteinases to mimic extracellular matrix secretion, but also portrayed fluorescence for labeling SAS tumor cells. Hence, the multifunctional CSCDs are expected to have potential for biomedical applications.
语种英语
WOS记录号WOS:000362436800060
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/146579
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
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Wang, Shu-Jun,Wang, Bei-Bei,Bai, Feng-Wu,et al. Tumor cell responses to carbon dots derived from chondroitin sulfate[J]. RSC ADVANCES,2015,5(99):81388-81394.
APA Wang, Shu-Jun,Wang, Bei-Bei,Bai, Feng-Wu,&Ma, Xiao-Jun.(2015).Tumor cell responses to carbon dots derived from chondroitin sulfate.RSC ADVANCES,5(99),81388-81394.
MLA Wang, Shu-Jun,et al."Tumor cell responses to carbon dots derived from chondroitin sulfate".RSC ADVANCES 5.99(2015):81388-81394.
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