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题名: Tumor cell responses to carbon dots derived from chondroitin sulfate
作者: Wang, Shu-Jun1, 2;  Wang, Bei-Bei2, 3;  Bai, Feng-Wu1, 4;  Ma, Xiao-Jun2
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra14585f
卷: 5, 期:99, 页:81388-81394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Mass production of carbon dots (CDs) derived from chondroitin sulfate (CS) was developed by the facile hydrothermal approach for the first time. The CS derived CDs (CSCDs) possessed good dispersibility and water solubility, bright blue and green luminescence, and relative pH- and photo-stable properties. Moreover, the multicolor CSCDs could be efficiently uptaken by SAS cells and exhibited low cytotoxicity. Therefore, the responses of human oral squamous cell carcinoma SAS cells to CSCDs were further investigated by evaluating their proliferation and invasion. Compared to CS, CSCDs not only provided higher efficiency for proliferation of SAS cells, and up-regulated expression of matrix metalloproteinases to mimic extracellular matrix secretion, but also portrayed fluorescence for labeling SAS tumor cells. Hence, the multifunctional CSCDs are expected to have potential for biomedical applications.
关键词[WOS]: GRAPHENE QUANTUM DOTS ;  MATRIX METALLOPROTEINASES ;  DRUG-DELIVERY ;  GREEN SYNTHESIS ;  CANCER-CELLS ;  GROWTH ;  INVASION ;  METASTASIS ;  NANODOTS ;  PHOTOLUMINESCENCE
语种: 英语
WOS记录号: WOS:000362436800060
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146579
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

Recommended Citation:
Wang, Shu-Jun,Wang, Bei-Bei,Bai, Feng-Wu,et al. Tumor cell responses to carbon dots derived from chondroitin sulfate[J]. RSC ADVANCES,2015,5(99):81388-81394.
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