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Tumor cell responses to carbon dots derived from chondroitin sulfate
Wang, Shu-Jun1,2; Wang, Bei-Bei2,3; Bai, Feng-Wu1,4; Ma, Xiao-Jun2
Source PublicationRSC ADVANCES
2015
DOI10.1039/c5ra14585f
Volume5Issue:99Pages:81388-81394
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordGRAPHENE QUANTUM DOTS ; MATRIX METALLOPROTEINASES ; DRUG-DELIVERY ; GREEN SYNTHESIS ; CANCER-CELLS ; GROWTH ; INVASION ; METASTASIS ; NANODOTS ; PHOTOLUMINESCENCE
AbstractMass production of carbon dots (CDs) derived from chondroitin sulfate (CS) was developed by the facile hydrothermal approach for the first time. The CS derived CDs (CSCDs) possessed good dispersibility and water solubility, bright blue and green luminescence, and relative pH- and photo-stable properties. Moreover, the multicolor CSCDs could be efficiently uptaken by SAS cells and exhibited low cytotoxicity. Therefore, the responses of human oral squamous cell carcinoma SAS cells to CSCDs were further investigated by evaluating their proliferation and invasion. Compared to CS, CSCDs not only provided higher efficiency for proliferation of SAS cells, and up-regulated expression of matrix metalloproteinases to mimic extracellular matrix secretion, but also portrayed fluorescence for labeling SAS tumor cells. Hence, the multifunctional CSCDs are expected to have potential for biomedical applications.
Language英语
WOS IDWOS:000362436800060
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/146579
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shu-Jun,Wang, Bei-Bei,Bai, Feng-Wu,et al. Tumor cell responses to carbon dots derived from chondroitin sulfate[J]. RSC ADVANCES,2015,5(99):81388-81394.
APA Wang, Shu-Jun,Wang, Bei-Bei,Bai, Feng-Wu,&Ma, Xiao-Jun.(2015).Tumor cell responses to carbon dots derived from chondroitin sulfate.RSC ADVANCES,5(99),81388-81394.
MLA Wang, Shu-Jun,et al."Tumor cell responses to carbon dots derived from chondroitin sulfate".RSC ADVANCES 5.99(2015):81388-81394.
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