中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery
作者: Wang, Ziyi1, 3;  Liao, Han3;  Wu, Hao3;  Wang, Beibei3;  Zhao, Haidong1;  Tan, Mingqian2
刊名: ANALYTICAL METHODS
发表日期: 2015
DOI: 10.1039/c5ay01978h
卷: 7, 期:20, 页:8911-8917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine ;  Technology
类目[WOS]: Chemistry, Analytical ;  Food Science & Technology ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Food Science & Technology ;  Spectroscopy
英文摘要: We report the finding of the presence of fluorescent carbon dots in commercial beer and TEM analysis reveals that the beer carbon dots (BCDs) have an average size of 2.5 nm. The BCDs possessed high solubility and excellent fluorescence properties under the excitation of ultra-violet light with a quantum yield of approximately 7.39%. X-ray photoelectron spectroscopy (XPS) characterization demonstrated that the BCDs contain carbon, oxygen and nitrogen, three elements with the relative contents ca. 59.52%, 36.71% and 3.77%, respectively. X-ray diffraction (XRD) analysis indicated that the BCDs are amorphous. Fourier transform infrared (FTIR) spectroscopy was employed to characterize the surface groups of the BCDs. The BCDs showed excellent stability under different conditions (high ion strength, extreme pH and laser exposure). The cytotoxicity study revealed that there was no obvious inhibition of cell viability with a concentration as high as 12.5 mg mL(-1) for 48 h, so that the BCDs could be directly applied in live cell imaging. Moreover, the BCDs could be used as efficient nanocarriers for the purpose of anticancer therapy. Doxorubicin-conjugated BCDs (BCD-DOX) induced prolonged cytotoxicity compared to free doxorubicin (DOX) due to the slow release of DOX from the BCD-DOX. The internalization of BCD-DOX by MCF-7 cells was further confirmed by using a laser scanning confocal microscope. All these results indicated that the BCDs present in beer have good biocompatibility and excellent fluorescence properties and may be considered as a safe material for bio-imaging and image-guided drug delivery in cancer therapy.
关键词[WOS]: MULTIFUNCTIONAL UNIMOLECULAR MICELLES ;  IRON-OXIDE NANOPARTICLES ;  IN-VIVO ;  MAGNETIC-RESONANCE ;  DOXORUBICIN ;  NANODOTS ;  PHOTOLUMINESCENCE ;  NANOTUBES ;  PROBES ;  ROUTE
语种: 英语
WOS记录号: WOS:000362662600056
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/146590
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
2.Dalian Polytech Univ, Sch Food Sci & Technol, Liaoning Key Lab Food Biol Technol, Dalian 116034, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Wang, Ziyi,Liao, Han,Wu, Hao,et al. Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery[J]. ANALYTICAL METHODS,2015,7(20):8911-8917.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, Ziyi]'s Articles
 [Liao, Han]'s Articles
 [Wu, Hao]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, Ziyi]‘s Articles
 [Liao, Han]‘s Articles
 [Wu, Hao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace