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Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment
Chen Cheng1; Wang Hong-Xi2; Kang Hong-Jian1; Yao Yao2; Qing Guang-Yan2; Li Xiu-Ling1; Liang Xin-Miao1
关键词Hydrophilic Interaction Chromatography Tetrapeptide Glycopeptide Enrichment Mass Spectrometry
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2017-08-01
DOI10.11895/j.issn.0253-3820.170165
45期:8页:1149-1154
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]N-LINKED GLYCOPEPTIDES ; SOLID-PHASE EXTRACTION ; MASS-SPECTROMETRY ; GLYCOSYLATION ; GLYCOPROTEINS ; HETEROGENEITY ; FETUIN
英文摘要In this study, a novel tetrapeptide hydrophilic interaction chromatography (HILIC) material was synthesized, and corresponding enrichment method for glycopeptides was developed. The tetrapeptide modified silica gel materials (denoted as Poly. DAPD) were synthesized by atom. transfer radical. polymerization (ATRP) and characterized by N-2 adsorption desorption and thermometer, thermal gravimetric analyzer (TGA) and X. ray photoelectron spectrometer (XPS). The characterization results indicated that tetrapeptide had been successfully synthesized on silica gel. Poly. DAPD materials showed high enrichment selectivity toward fetuin glycopeptides under solid. phase extraction (SPE) mode. Comparing with commercialized ZIC. HILIC in glycopeptides enrichment of fetuin digest which mixed with 5 mole ratio of albumin bovine (BSA), the as. prepared materials showed higher selectivity in both aspects of the identified number of glycopeptides and anti. interference property. The SPE results demonstrated that the tetrapeptide. based HILIC materials could be a potential tool in large. scale glycosylation analysis.
语种英语
WOS记录号WOS:000414612900006
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/149674
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hubei, Peoples R China
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Chen Cheng,Wang Hong-Xi,Kang Hong-Jian,et al. Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2017,45(8):1149-1154.
APA Chen Cheng.,Wang Hong-Xi.,Kang Hong-Jian.,Yao Yao.,Qing Guang-Yan.,...&Liang Xin-Miao.(2017).Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,45(8),1149-1154.
MLA Chen Cheng,et al."Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 45.8(2017):1149-1154.
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