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题名: Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment
作者: Chen Cheng1;  Wang Hong-Xi2;  Kang Hong-Jian1;  Yao Yao2;  Qing Guang-Yan2;  Li Xiu-Ling1;  Liang Xin-Miao1
关键词: Hydrophilic interaction chromatography ;  Tetrapeptide ;  Glycopeptide enrichment ;  Mass spectrometry
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2017-08-01
DOI: 10.11895/j.issn.0253-3820.170165
卷: 45, 期:8, 页:1149-1154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: In this study, a novel tetrapeptide hydrophilic interaction chromatography (HILIC) material was synthesized, and corresponding enrichment method for glycopeptides was developed. The tetrapeptide modified silica gel materials (denoted as Poly. DAPD) were synthesized by atom. transfer radical. polymerization (ATRP) and characterized by N-2 adsorption desorption and thermometer, thermal gravimetric analyzer (TGA) and X. ray photoelectron spectrometer (XPS). The characterization results indicated that tetrapeptide had been successfully synthesized on silica gel. Poly. DAPD materials showed high enrichment selectivity toward fetuin glycopeptides under solid. phase extraction (SPE) mode. Comparing with commercialized ZIC. HILIC in glycopeptides enrichment of fetuin digest which mixed with 5 mole ratio of albumin bovine (BSA), the as. prepared materials showed higher selectivity in both aspects of the identified number of glycopeptides and anti. interference property. The SPE results demonstrated that the tetrapeptide. based HILIC materials could be a potential tool in large. scale glycosylation analysis.
关键词[WOS]: N-LINKED GLYCOPEPTIDES ;  SOLID-PHASE EXTRACTION ;  MASS-SPECTROMETRY ;  GLYCOSYLATION ;  GLYCOPROTEINS ;  HETEROGENEITY ;  FETUIN
语种: 英语
WOS记录号: WOS:000414612900006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149674
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hubei, Peoples R China

Recommended Citation:
Chen Cheng,Wang Hong-Xi,Kang Hong-Jian,et al. Novel Tetrapeptide Hydrophilic Interaction Chromatography Materials for High. efficiency Glycopeptide Enrichment[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2017,45(8):1149-1154.
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