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Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging
Dou, Ya-Kun1; Chen, Yang2; He, Xi-Wen1; Li, Wen-You1,3; Li, Yu-Hao2; Zhang, Yu-Kui1,4
Source PublicationANALYTICAL CHEMISTRY
2017-11-07
DOI10.1021/acs.analchem.7b01644
Volume89Issue:21Pages:11286-11292
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPOT MICROWAVE SYNTHESIS ; ZEBRAFISH DANIO-RERIO ; QUANTUM DOTS ; IN-VIVO ; MULTIFUNCTIONAL NANOPARTICLES ; HIGHLY FLUORESCENT ; PROBES ; PHOTOLUMINESCENCE ; NANOCRYSTALS ; CELLS
AbstractSilicon nanoparticles (Si NPs) have been widely used in fluorescence imaging. However, rigorous synthesis conditions and the single modality imaging limit the further development of Si NPs in the field of biomedical imaging. Here, we reported a method for synthesizing water-dispersible Mn2+ functionalized Si NPs (Mn-Si NPs) under mild experimental conditions for fluorescence and magnetic resonance dual-modality imaging. The whole synthesis process was completed under room temperature and atmospheric pressure, and no special and expensive equipment was required. The synthetic nanoparticles, with favorable pH stability, NaCl stability, photostability, and low toxicity, emitted green fluorescence (512 nrn). At the same time, the nanoparticles also demonstrated excellent magnetic resonance imaging ability. In vitro, their T-1-weighted magnetic resonance imaging effect was obvious, and the value of longitudinal relaxation degree r(1) reached 4.25 mM(-1) s(-1). On the basis of their good biocompatibility, Mn-Si NPs were successfully used for the fluorescence imaging as well as magnetic resonance imaging in vivo.
Language英语
WOS IDWOS:000414887000021
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/149702
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Nankai Univ, Sch Med, Key Lab Tumor Microenvironm & Neurovasc Regulat, Tianjin 300071, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Dou, Ya-Kun,Chen, Yang,He, Xi-Wen,et al. Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging[J]. ANALYTICAL CHEMISTRY,2017,89(21):11286-11292.
APA Dou, Ya-Kun,Chen, Yang,He, Xi-Wen,Li, Wen-You,Li, Yu-Hao,&Zhang, Yu-Kui.(2017).Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging.ANALYTICAL CHEMISTRY,89(21),11286-11292.
MLA Dou, Ya-Kun,et al."Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging".ANALYTICAL CHEMISTRY 89.21(2017):11286-11292.
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