中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots
作者: Chang, Lifang1;  Wu, Haocheng1;  He, Xiwen1;  Chen, Langxing1, 2;  Zhang, Yukui1, 3
关键词: Mn-doped ZnS quantum dots ;  Fluorescent sensor ;  Turn-on ;  Boronate affinity ;  Glycoproteins
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2017-12-01
DOI: 10.1016/j.aca.2017.09.037
卷: 995, 页:91-98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A simple fluorescence turn-on sensor has been designed for the highly sensitive detection of glycoproteins on the basis of boronic acid functional polymer capped Mn-doped ZnS quantum dots (QDs@MPS@AAPBA). In the absence of glycoproteins, the fluorescence emission intensity of the QDs@MPS@AAPBA was relatively weaker due to the effective electronic transfer from the QDs to the boron moieties on its surface. While the glycoproteins were introduced into the system, an obvious fluorescence enhancement was observed. It was attributed to the boron moieties covalent binding gly-cans of the glycoproteins resulting in the electronic transfer process being inhibited. Under the optimal conditions, this fluorescent probe not only could be applied in a wide pH range of 5.0-9.0, but also the binding constants and detection limits of the QDs@MPS@AAPBA for horseradish peroxidase (HRP) and transferrin (TRF) were up to 7.23 x 10(6) M-1, 1.53 x 10(7) M-1 and 1.44 x 10(-10) M, 3.36 x 10(-10) M, respectively. Finally, this proposed method has also been utilized for the TRF determination in serum without any complicated pretreatment and the recovery was in the range of 95.7%-103.0%. As a result, it is promising for application on the glycoproteins detection in complex biological samples. (C) 2017 Elsevier B.V. All rights reserved.
关键词[WOS]: MOLECULARLY IMPRINTED POLYMER ;  DRUG-DELIVERY ;  IN-VIVO ;  AFFINITY ;  CELLS ;  CAPILLARY ;  RECEPTOR ;  GLUCOSE ;  SURFACE ;  PROBE
语种: 英语
WOS记录号: WOS:000414540200009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149751
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Nankai Univ, Res Ctr Analyt Sci, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Chang, Lifang,Wu, Haocheng,He, Xiwen,et al. A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots[J]. ANALYTICA CHIMICA ACTA,2017,995:91-98.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Chang, Lifang]'s Articles
 [Wu, Haocheng]'s Articles
 [He, Xiwen]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Chang, Lifang]‘s Articles
 [Wu, Haocheng]‘s Articles
 [He, Xiwen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace