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A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots
Chang, Lifang1; Wu, Haocheng1; He, Xiwen1; Chen, Langxing1,2; Zhang, Yukui1,3
KeywordMn-doped Zns Quantum Dots Fluorescent Sensor Turn-on Boronate Affinity Glycoproteins
Source PublicationANALYTICA CHIMICA ACTA
2017-12-01
DOI10.1016/j.aca.2017.09.037
Volume995Pages:91-98
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordMOLECULARLY IMPRINTED POLYMER ; DRUG-DELIVERY ; IN-VIVO ; AFFINITY ; CELLS ; CAPILLARY ; RECEPTOR ; GLUCOSE ; SURFACE ; PROBE
AbstractA simple fluorescence turn-on sensor has been designed for the highly sensitive detection of glycoproteins on the basis of boronic acid functional polymer capped Mn-doped ZnS quantum dots (QDs@MPS@AAPBA). In the absence of glycoproteins, the fluorescence emission intensity of the QDs@MPS@AAPBA was relatively weaker due to the effective electronic transfer from the QDs to the boron moieties on its surface. While the glycoproteins were introduced into the system, an obvious fluorescence enhancement was observed. It was attributed to the boron moieties covalent binding gly-cans of the glycoproteins resulting in the electronic transfer process being inhibited. Under the optimal conditions, this fluorescent probe not only could be applied in a wide pH range of 5.0-9.0, but also the binding constants and detection limits of the QDs@MPS@AAPBA for horseradish peroxidase (HRP) and transferrin (TRF) were up to 7.23 x 10(6) M-1, 1.53 x 10(7) M-1 and 1.44 x 10(-10) M, 3.36 x 10(-10) M, respectively. Finally, this proposed method has also been utilized for the TRF determination in serum without any complicated pretreatment and the recovery was in the range of 95.7%-103.0%. As a result, it is promising for application on the glycoproteins detection in complex biological samples. (C) 2017 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000414540200009
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/149751
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, Res Ctr Analyt Sci, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Chang, Lifang,Wu, Haocheng,He, Xiwen,et al. A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots[J]. ANALYTICA CHIMICA ACTA,2017,995:91-98.
APA Chang, Lifang,Wu, Haocheng,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2017).A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots.ANALYTICA CHIMICA ACTA,995,91-98.
MLA Chang, Lifang,et al."A highly sensitive fluorescent turn-on biosensor for glycoproteins based on boronic acid functional polymer capped Mn-doped ZnS quantum dots".ANALYTICA CHIMICA ACTA 995(2017):91-98.
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