DICP OpenIR
Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling
Tan, Xiao-Hua1; Zheng, Xiao-Meng1; Yu, Li-Xia1; He, Jian2; Zhu, Hong-Mei1; Ge, Xiu-Ping3; Ren, Xiao-Li4; Ye, Fa-Qing1; Bellusci, Saverio5,6; Xiao, Jian1; Li, Xiao-Kun1,5; Zhang, Jin-San1,5
KeywordFibroblast Growth Factor 2 High-mobility Group Box 1 Ischaemia-reperfusion Acute Kidney Injury Mitochondrial Dysfunction Inflammatory Cytokine
Source PublicationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE
2017-11-01
DOI10.1111/jcmm.13203
Volume21Issue:11Pages:2909-2925
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectCell Biology ; Medicine, Research & Experimental
WOS Research AreaCell Biology ; Research & Experimental Medicine
WOS KeywordISCHEMIA-REPERFUSION INJURY ; ACUTE KIDNEY INJURY ; CARDIAC-SPECIFIC OVEREXPRESSION ; SENSITIVE K+-CHANNEL ; DEPENDENT POTASSIUM CHANNEL ; OXIDATIVE STRESS ; REACTIVE OXYGEN ; NEPHROGENIC PROTEINS ; CEREBRAL-ISCHEMIA ; CELL APOPTOSIS
AbstractIschaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model. FGF2 treatment greatly alleviated I/R-induced acute renal dysfunction and largely blunted I/R-induced elevation in serum creatinine and blood urea nitrogen, and also the number of TUNEL-positive tubular cells in the kidney. Mechanistically, FGF2 substantially ameliorated renal I/RI by mitigating several mitochondria damaging parameters including pro-apoptotic alteration of Bcl2/Bax expression, caspase-3 activation, loss of mitochondrial membrane potential and K-ATP channel integrity. Of note, the protective effect of FGF2 was significantly compromised by the K-ATP channel blocker 5-HD. Interestingly, I/RI alone resulted in mild activation of FGFR, whereas FGF2 treatment led to more robust receptor activation. More significantly, post-I/RI administration of FGF2 also exhibited robust protection against I/RI by reducing cell apoptosis, inhibiting the release of damage-associated molecular pattern molecule HMBG1 and activation of its downstream inflammatory cytokines such as IL-1 alpha, IL-6 and TNF alpha. Taken together, our data suggest that FGF2 offers effective protection against I/RI and improves animal survival by attenuating mitochondrial damage and HMGB1-mediated inflammatory response. Therefore, FGF2 has the potential to be used for the prevention and treatment of I/RI-induced AKI.
Language英语
WOS IDWOS:000413962100024
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/149764
Collection中国科学院大连化学物理研究所
Affiliation1.Wenzhou Med Univ, Sch Pharmaceut Sci, Key Lab Biotechnol & Pharmaceut Engn, Wenzhou, Zhejiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Ctr Translat Med, Dalian, Liaoning, Peoples R China
3.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat Surg, Xian, Shaanxi, Peoples R China
4.Wenzhou Med Univ, Lab Anim Ctr, Wenzhou, Zhejiang, Peoples R China
5.Wenzhou Univ, Inst Life Sci, Wenzhou, Peoples R China
6.Justus Liebig Univ, Excellence Cluster Cardiopulm Syst, Giessen, Germany
Recommended Citation
GB/T 7714
Tan, Xiao-Hua,Zheng, Xiao-Meng,Yu, Li-Xia,et al. Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(11):2909-2925.
APA Tan, Xiao-Hua.,Zheng, Xiao-Meng.,Yu, Li-Xia.,He, Jian.,Zhu, Hong-Mei.,...&Zhang, Jin-San.(2017).Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,21(11),2909-2925.
MLA Tan, Xiao-Hua,et al."Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21.11(2017):2909-2925.
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