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Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging
Dou, Ya-Kun1; Chen, Yang2; He, Xi-Wen1; Li, Wen-You1,3; Li, Yu-Hao2; Zhang, Yu-Kui1,4
刊名ANALYTICAL CHEMISTRY
2017-11-07
DOI10.1021/acs.analchem.7b01644
89期:21页:11286-11292
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]POT MICROWAVE SYNTHESIS ; ZEBRAFISH DANIO-RERIO ; QUANTUM DOTS ; IN-VIVO ; MULTIFUNCTIONAL NANOPARTICLES ; HIGHLY FLUORESCENT ; PROBES ; PHOTOLUMINESCENCE ; NANOCRYSTALS ; CELLS
英文摘要Silicon nanoparticles (Si NPs) have been widely used in fluorescence imaging. However, rigorous synthesis conditions and the single modality imaging limit the further development of Si NPs in the field of biomedical imaging. Here, we reported a method for synthesizing water-dispersible Mn2+ functionalized Si NPs (Mn-Si NPs) under mild experimental conditions for fluorescence and magnetic resonance dual-modality imaging. The whole synthesis process was completed under room temperature and atmospheric pressure, and no special and expensive equipment was required. The synthetic nanoparticles, with favorable pH stability, NaCl stability, photostability, and low toxicity, emitted green fluorescence (512 nrn). At the same time, the nanoparticles also demonstrated excellent magnetic resonance imaging ability. In vitro, their T-1-weighted magnetic resonance imaging effect was obvious, and the value of longitudinal relaxation degree r(1) reached 4.25 mM(-1) s(-1). On the basis of their good biocompatibility, Mn-Si NPs were successfully used for the fluorescence imaging as well as magnetic resonance imaging in vivo.
语种英语
WOS记录号WOS:000414887000021
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/149765
专题中国科学院大连化学物理研究所
作者单位1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Nankai Univ, Sch Med, Key Lab Tumor Microenvironm & Neurovasc Regulat, Tianjin 300071, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
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GB/T 7714
Dou, Ya-Kun,Chen, Yang,He, Xi-Wen,et al. Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging[J]. ANALYTICAL CHEMISTRY,2017,89(21):11286-11292.
APA Dou, Ya-Kun,Chen, Yang,He, Xi-Wen,Li, Wen-You,Li, Yu-Hao,&Zhang, Yu-Kui.(2017).Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging.ANALYTICAL CHEMISTRY,89(21),11286-11292.
MLA Dou, Ya-Kun,et al."Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging".ANALYTICAL CHEMISTRY 89.21(2017):11286-11292.
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