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题名: Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways
作者: Shi, Yun Wei1, 2, 3;  Zhang, Xiao Chuan1, 2, 3;  Chen, Chen1, 2, 3;  Tang, Miao1, 2, 3;  Wang, Zhi Wei1, 2, 3, 4;  Liang, Xin Miao1, 2, 3, 5;  Ding, Fei1, 2, 3;  Wang, Cai Ping1, 2, 3
关键词: C5aR1 ;  TLR4 ;  Schisantherin A ;  Inflammation ;  Apoptosis ;  Neuroprotection
刊名: BRAIN BEHAVIOR AND IMMUNITY
发表日期: 2017-11-01
DOI: 10.1016/j.bbi.2017.07.004
卷: 66, 页:244-256
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Immunology ;  Neurosciences
研究领域[WOS]: Immunology ;  Neurosciences & Neurology
英文摘要: Toll-like receptor 4 (TLR4) and C5aR1 (CD88) have been recognized as potential therapeutic targets for the reduction of inflammation and secondary damage and improvement of outcome after ischemia and reperfusion (I/R). The inflammatory responses which induce cell apoptosis and necrosis after I/R brain injury lead to a limited process of neural repair. To further comprehend how these targets function in I/R state, we investigated the pathological changes and TLR4 and C5aR1 signaling pathways in vitro and in vivo models of I/12 brain injury in this study. Meanwhile, we explored the roles of schisantherin A on I/R brain injury, and whether it exerted neuroprotective effects by regulating the TLR4 and C5aR1 signaling pathways or not. The results showed that schisantherin A significantly reduced the neuronal apoptosis induced by oxygen and glucose deprivation and reperfusion (OGD/R) injury in primary culture of rat cortical neurons. Also, schisantherin A alleviated neurological deficits, reduced infarct volume, attenuated oxidation stress, inflammation and apoptosis in ischemic parietal cortex of rats after middle cerebral artery occlusion and reperfusion (MCAO/R) injury. Moreover, the activated TLR4 and C5aR1 signaling pathways were inhibited by schisantherin A treatment. In conclusion, TLR4 and C5aR1 played a vital role during I/R. brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways. These findings also provided new insights that would aid in elucidating the effect of schisantherin A against cerebral I/12 and support the development of schisantherin A as a potential treatment for ischemic stroke. (C) 2017 Elsevier Inc. All rights reserved.
关键词[WOS]: FOCAL CEREBRAL-ISCHEMIA ;  NF-KAPPA-B ;  IN-VIVO ;  DIBENZOCYCLOOCTADIENE LIGNANS ;  FUNCTIONAL RECOVERY ;  BRAIN-INJURY ;  ACUTE STROKE ;  PROTECTS ;  COMPLEMENT ;  RECEPTOR
语种: 英语
WOS记录号: WOS:000414236600025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149776
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
2.Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China
4.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Shi, Yun Wei,Zhang, Xiao Chuan,Chen, Chen,et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways[J]. BRAIN BEHAVIOR AND IMMUNITY,2017,66:244-256.
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