DICP OpenIR
Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways
Shi, Yun Wei1,2,3; Zhang, Xiao Chuan1,2,3; Chen, Chen1,2,3; Tang, Miao1,2,3; Wang, Zhi Wei1,2,3,4; Liang, Xin Miao1,2,3,5; Ding, Fei1,2,3; Wang, Cai Ping1,2,3
KeywordC5ar1 Tlr4 Schisantherin a Inflammation Apoptosis Neuroprotection
Source PublicationBRAIN BEHAVIOR AND IMMUNITY
2017-11-01
DOI10.1016/j.bbi.2017.07.004
Volume66Pages:244-256
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectImmunology ; Neurosciences
WOS Research AreaImmunology ; Neurosciences & Neurology
WOS KeywordFOCAL CEREBRAL-ISCHEMIA ; NF-KAPPA-B ; IN-VIVO ; DIBENZOCYCLOOCTADIENE LIGNANS ; FUNCTIONAL RECOVERY ; BRAIN-INJURY ; ACUTE STROKE ; PROTECTS ; COMPLEMENT ; RECEPTOR
AbstractToll-like receptor 4 (TLR4) and C5aR1 (CD88) have been recognized as potential therapeutic targets for the reduction of inflammation and secondary damage and improvement of outcome after ischemia and reperfusion (I/R). The inflammatory responses which induce cell apoptosis and necrosis after I/R brain injury lead to a limited process of neural repair. To further comprehend how these targets function in I/R state, we investigated the pathological changes and TLR4 and C5aR1 signaling pathways in vitro and in vivo models of I/12 brain injury in this study. Meanwhile, we explored the roles of schisantherin A on I/R brain injury, and whether it exerted neuroprotective effects by regulating the TLR4 and C5aR1 signaling pathways or not. The results showed that schisantherin A significantly reduced the neuronal apoptosis induced by oxygen and glucose deprivation and reperfusion (OGD/R) injury in primary culture of rat cortical neurons. Also, schisantherin A alleviated neurological deficits, reduced infarct volume, attenuated oxidation stress, inflammation and apoptosis in ischemic parietal cortex of rats after middle cerebral artery occlusion and reperfusion (MCAO/R) injury. Moreover, the activated TLR4 and C5aR1 signaling pathways were inhibited by schisantherin A treatment. In conclusion, TLR4 and C5aR1 played a vital role during I/R. brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways. These findings also provided new insights that would aid in elucidating the effect of schisantherin A against cerebral I/12 and support the development of schisantherin A as a potential treatment for ischemic stroke. (C) 2017 Elsevier Inc. All rights reserved.
Language英语
WOS IDWOS:000414236600025
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/149776
Collection中国科学院大连化学物理研究所
Affiliation1.Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
2.Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China
4.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Shi, Yun Wei,Zhang, Xiao Chuan,Chen, Chen,et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways[J]. BRAIN BEHAVIOR AND IMMUNITY,2017,66:244-256.
APA Shi, Yun Wei.,Zhang, Xiao Chuan.,Chen, Chen.,Tang, Miao.,Wang, Zhi Wei.,...&Wang, Cai Ping.(2017).Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways.BRAIN BEHAVIOR AND IMMUNITY,66,244-256.
MLA Shi, Yun Wei,et al."Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways".BRAIN BEHAVIOR AND IMMUNITY 66(2017):244-256.
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