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题名: Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?
作者: Xie, Peng1;  Zhang, Yan1
关键词: Congenital stationary night blindness ;  Retinal isomers ;  QM/MM ;  Thermal stability ;  Thermal isomerization barrier
刊名: THEORETICAL CHEMISTRY ACCOUNTS
发表日期: 2016-12-19
DOI: 10.1007/s00214-016-2039-x
卷: 136, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: The thermal stability and thermal activity of four G90D rhodopsin isomer models were investigated by QM/MM method. The results implied that one pathological mechanism of congenital stationary night blindness caused by G90D mutation is the low thermal isomerization barrier of G90D rhodopsin binding with 11-cis retinal, not just the lacking of natural salt bridge. 9-cis retinal binding with G90D rhodopsin opsin could increase the thermal stability and minimize the thermal isomerization of G90D rhodopsin mutant. Therefore, 9-cis retinal was suggested to be used in potential treatments for congenital stationary night blindness caused by G90D mutation.
关键词[WOS]: VISUAL PIGMENT ;  7-CIS ISOMERS ;  MUTATION ;  MECHANISM ;  PROTEIN ;  PHOTOISOMERIZATION ;  ACTIVATION ;  MUTANTS ;  PHOTORECEPTOR ;  ISORHODOPSIN
语种: 英语
WOS记录号: WOS:000406775500001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149810
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Xie, Peng,Zhang, Yan. Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?[J]. THEORETICAL CHEMISTRY ACCOUNTS,2016,136(1).
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