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题名: Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
作者: Wu, Qi1;  Zhou, Lina2;  Sun, Xin3;  Yan, Zhongfang4;  Hu, Chunxiu2;  Wu, Junping3;  Xu, Long3;  Li, Xue5;  Liu, Huiling6;  Yin, Peiyuan2;  Li, Kuan5;  Zhao, Jieyu2;  Li, Yanli2, 5;  Wang, Xiaolin2, 5;  Li, Yu;  Zhang, Qiuyang;  Xu, Guowang2;  Chen, Huaiyong1, 5
刊名: SCIENTIFIC REPORTS
发表日期: 2017-08-22
DOI: 10.1038/s41598-017-09536-z
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.
关键词[WOS]: ACUTE RESPIRATORY SYNDROME ;  HONG-KONG ;  CANNABINOID RECEPTOR ;  HUMAN EMERGENCE ;  CORONAVIRUS ;  GPR55 ;  THERAPY ;  LYSOPHOSPHATIDYLINOSITOL ;  IDENTIFICATION ;  OSTEONECROSIS
语种: 英语
WOS记录号: WOS:000408165400001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149812
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Tianjin Med Univ, Tianjin Inst Resp Dis, Haihe Clin Coll, Key Res Lab Infect Dis Prevent,State Adm Tradit C, Tianjin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Tianjin Haihe Hosp, Dept Resp Med, Tianjin, Peoples R China
4.Tianjin Haihe Hosp, Dept Nutr, Tianjin, Peoples R China
5.Tianjin Haihe Hosp, Dept Basic Med, Tianjin, Peoples R China
6.Tianjin Haihe Hosp, Dept Gastroenterol, Tianjin, Peoples R China

Recommended Citation:
Wu, Qi,Zhou, Lina,Sun, Xin,et al. Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection[J]. SCIENTIFIC REPORTS,2017,7.
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