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Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?
Xie, Peng; Zhang, Yan
关键词Congenital Stationary Night Blindness Retinal Isomers Qm/mm Thermal Stability Thermal Isomerization Barrier
刊名THEORETICAL CHEMISTRY ACCOUNTS
2016-12-19
DOI10.1007/s00214-016-2039-x
136期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]VISUAL PIGMENT ; 7-CIS ISOMERS ; MUTATION ; MECHANISM ; PROTEIN ; PHOTOISOMERIZATION ; ACTIVATION ; MUTANTS ; PHOTORECEPTOR ; ISORHODOPSIN
英文摘要The thermal stability and thermal activity of four G90D rhodopsin isomer models were investigated by QM/MM method. The results implied that one pathological mechanism of congenital stationary night blindness caused by G90D mutation is the low thermal isomerization barrier of G90D rhodopsin binding with 11-cis retinal, not just the lacking of natural salt bridge. 9-cis retinal binding with G90D rhodopsin opsin could increase the thermal stability and minimize the thermal isomerization of G90D rhodopsin mutant. Therefore, 9-cis retinal was suggested to be used in potential treatments for congenital stationary night blindness caused by G90D mutation.
语种英语
WOS记录号WOS:000406775500001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/149820
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China
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Xie, Peng,Zhang, Yan. Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?[J]. THEORETICAL CHEMISTRY ACCOUNTS,2016,136(1).
APA Xie, Peng,&Zhang, Yan.(2016).Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?.THEORETICAL CHEMISTRY ACCOUNTS,136(1).
MLA Xie, Peng,et al."Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?".THEORETICAL CHEMISTRY ACCOUNTS 136.1(2016).
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