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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
Wu, Qi1; Zhou, Lina2; Sun, Xin3; Yan, Zhongfang4; Hu, Chunxiu2; Wu, Junping3; Xu, Long3; Li, Xue5; Liu, Huiling6; Yin, Peiyuan2; Li, Kuan5; Zhao, Jieyu2; Li, Yanli2,5; Wang, Xiaolin2,5; Li, Yu; Zhang, Qiuyang; Xu, Guowang2; Chen, Huaiyong1,5
刊名SCIENTIFIC REPORTS
2017-08-22
DOI10.1038/s41598-017-09536-z
7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACUTE RESPIRATORY SYNDROME ; HONG-KONG ; CANNABINOID RECEPTOR ; HUMAN EMERGENCE ; CORONAVIRUS ; GPR55 ; THERAPY ; LYSOPHOSPHATIDYLINOSITOL ; IDENTIFICATION ; OSTEONECROSIS
英文摘要Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.
语种英语
WOS记录号WOS:000408165400001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/149822
专题中国科学院大连化学物理研究所
作者单位1.Tianjin Med Univ, Tianjin Inst Resp Dis, Haihe Clin Coll, Key Res Lab Infect Dis Prevent,State Adm Tradit C, Tianjin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Tianjin Haihe Hosp, Dept Resp Med, Tianjin, Peoples R China
4.Tianjin Haihe Hosp, Dept Nutr, Tianjin, Peoples R China
5.Tianjin Haihe Hosp, Dept Basic Med, Tianjin, Peoples R China
6.Tianjin Haihe Hosp, Dept Gastroenterol, Tianjin, Peoples R China
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GB/T 7714
Wu, Qi,Zhou, Lina,Sun, Xin,et al. Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection[J]. SCIENTIFIC REPORTS,2017,7.
APA Wu, Qi.,Zhou, Lina.,Sun, Xin.,Yan, Zhongfang.,Hu, Chunxiu.,...&Chen, Huaiyong.(2017).Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.SCIENTIFIC REPORTS,7.
MLA Wu, Qi,et al."Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection".SCIENTIFIC REPORTS 7(2017).
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