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题名: 4 '-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice
作者: Fan, Chao1;  Wu, Le-Hao1;  Zhang, Gu-Fang1;  Xu, Fangfang2;  Zhang, Shuo1;  Zhang, Xiuli2;  Sun, Lei1;  Yu, Yang1;  Zhang, Yan1;  Ye, Richard D.1, 3
刊名: PLOS ONE
发表日期: 2017-08-08
DOI: 10.1371/journal.pone.0181191
卷: 12, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: 4'-Hydroxywogonin (4'-HW), a flavonoid, has been isolated from various plants and shown to inhibit NO production in macrophages. However, the molecular mechanisms and its in vivo activity have not been determined. Our study aimed to investigate the mechanisms underlying the anti-inflammatory effects of 4'-HW in vitro and in vivo. We showed that 4'-HW potently reduced the expression levels of COX-2 and iNOS as well as their products, prostaglandin E2 (PGE2) and nitric oxide (NO) respectively, in LPS-stimulated RAW 264.7 macrophages. 4'-HW also suppressed LPS-induced pro-inflammatory cytokines at mRNA and protein levels. Moreover, 4'-HW blocked the interaction of TAK1 and TAB1 in LPS-stimulated RAW 264.7 macrophages, resulting in an inhibition of the TAK1/IKK/NF-kappa B signaling pathway. Furthermore, 4'-HW also reduced the phosphorylation of MAPKs and PI3/Akt signaling pathways in LPS-stimulated RAW 264.7 macrophages. 4'-HW was also significantly decreased the intracellular reactive oxygen species (ROS) level. The effect of 4'-HW was confirmed in vivo. 4'-HW exhibited potent protective effect against LPS-induced ALI in mice. These findings indicate that 4'-HW suppresses the LPS-induced response in vitro and in vivo. It is likely that the inhibition of the TAK1/IKK/NF-kappa B, MAPKs and PI3/AKT signaling pathways contribute to the anti-inflammatory effects of 4'-HW. Our study suggests that 4'-HW may be an important functional constituent in the plants and has the potential value to be developed as a novel anti-inflammatory agent.
关键词[WOS]: NF-KAPPA-B ;  ANTIINFLAMMATORY ACTIVITY ;  PROTEIN-KINASES ;  GENE-EXPRESSION ;  P38 MAPK ;  WOGONIN ;  ACTIVATION ;  PATHWAYS ;  PHOSPHORYLATION ;  ALPHA
语种: 英语
WOS记录号: WOS:000407144700004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149830
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China

Recommended Citation:
Fan, Chao,Wu, Le-Hao,Zhang, Gu-Fang,et al. 4 '-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice[J]. PLOS ONE,2017,12(8).
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