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题名: Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry
作者: Liu, Shuxin1;  Wang, Lichao2, 3, 5;  Hu, Chunxiu2, 5;  Huang, Xin4;  Liu, Hong1;  Xuan, Qiuhui2, 5;  Lin, Xiaohui4;  Peng, Xiaojun3;  Lu, Xin2, 5;  Chang, Ming1;  Xu, Guowang2, 5
刊名: SCIENTIFIC REPORTS
发表日期: 2017-08-15
DOI: 10.1038/s41598-017-08327-w
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Uremia has been a rapidly increasing health problem in China. Hemodialysis (HD) is the main renal replacement therapy for uremia. The results of large-scale clinical trials have shown that the HD pattern is crucial for long-term prognosis of maintenance hemodialysis (MHD) in uremic patients. Plasma metabolism is very important for revealing the biological insights linked to the therapeutic effects of the HD pattern on uremia. Alteration of plasma metabolites in uremic patients in response to HD therapy has been reported. However, HD-pattern-dependent changes in plasma metabolites remain poorly understood. To this end, a capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics method was performed to systemically study the differences between HD and high flux hemodialysis (HFD) on plasma metabolite changes in patients. Three hundred and one plasma samples from three independent human cohorts (i.e., healthy controls, patients with pre-HD/post-HD, and patients with pre-HFD/post-HFD) were used in this study. Metabolites significantly changed (p < 0.05) after a single HD or HFD process. However, 11 uremic retention solutes could be more efficiently removed by HFD. Our findings indicate that a CE-TOF/MS-based metabolomics approach is promising for providing novel insights into understanding the effects of different dialysis methods on metabolite alterations of uremia.
关键词[WOS]: STAGE RENAL-DISEASE ;  ARYL-HYDROCARBON RECEPTOR ;  CHRONIC KIDNEY-DISEASE ;  INDOLEAMINE 2,3-DIOXYGENASE ;  GUANIDINO COMPOUNDS ;  OXIDATIVE STRESS ;  PROTEIN-BINDING ;  SERUM ;  TRANSPORTER ;  ARGININE
语种: 英语
WOS记录号: WOS:000407570000027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/149894
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Municipal Cent Hosp, Dept Nephrol, 826 Xinan Rd, Dalian 116033, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
4.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian 116024, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Liu, Shuxin,Wang, Lichao,Hu, Chunxiu,et al. Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry[J]. SCIENTIFIC REPORTS,2017,7.
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