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Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
Yang, Rui-xu1; Hu, Chun-xiu2; Sun, Wan-lu1; Pan, Qin1; Shen, Feng1; Yang, Zhen3; Su, Qing3; Xu, Guo-wang2; Fan, Jian-gao1
Source PublicationSCIENTIFIC REPORTS
2017-09-05
DOI10.1038/s41598-017-11278-x
Volume7
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordCONTROLLED ATTENUATION PARAMETER ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; VIRUS INFECTION ; STEATOSIS ; FIBROSIS ; PLASMALOGENS ; PERFORMANCE ; PROGRESSION ; BIOMARKERS
AbstractChronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n = 23) and of biopsy-proven NAFLD (n = 42), CHB with NAFLD (n = 22) and without NAFLD (n = 17) were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. There were distinct serum lipidome between groups of NAFLD and CHB without NAFLD. Most of the neutral lipids and ceramide were elevated in the NAFLD group but were decreased in the CHB without NAFLD group. Plasmalogens were decreased in both groups. Triacylglycerols (TAGs) with lower carbon numbers and double bonds were increased in subjects with NASH. Serum monounsaturated TAG was a significant predictor of NASH (OR = 3.215; 95% CI 1.663-6.331) and positively correlated with histological activity (r = 0.501; P < 0.001). It showed good predictability for NASH in the NAFLD group [area under the receiver operating characteristic curves (AUROC) = 0.831] and was validated in the CHB group (AUROC = 0.833); this characteristic was superior to that of cytokeratin-18 and alanine transaminase. The increase in monounsaturated TAG might be a specific marker for NASH in both NAFLD and CHB patients.
Language英语
WOS IDWOS:000409309300105
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/149913
Collection中国科学院大连化学物理研究所
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol,Ctr Fatty Liver, Shanghai 200092, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China
Recommended Citation
GB/T 7714
Yang, Rui-xu,Hu, Chun-xiu,Sun, Wan-lu,et al. Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B[J]. SCIENTIFIC REPORTS,2017,7.
APA Yang, Rui-xu.,Hu, Chun-xiu.,Sun, Wan-lu.,Pan, Qin.,Shen, Feng.,...&Fan, Jian-gao.(2017).Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B.SCIENTIFIC REPORTS,7.
MLA Yang, Rui-xu,et al."Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B".SCIENTIFIC REPORTS 7(2017).
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