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题名: The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide
作者: Xu, Qingsong1, 2;  Liu, Meisi1;  Liu, Qishun1;  Wang, Wenxia1;  Du, Yuguang3;  Yin, Heng1
关键词: N-acetylated chitooligosaccharide ;  Lipopolysaccharides ;  Interleukin-6 ;  Tumor necrosis factor-alpha ;  Inflammation ;  PI3K/Akt pathway
刊名: CARBOHYDRATE POLYMERS
发表日期: 2017-10-15
DOI: 10.1016/j.carbpol.2017.07.051
卷: 174, 页:1138-1143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitooligosaccharide (COS) has been shown to regulate many biological functions, such as antimicrobial effect and antitumor activity. In the present study, highly N-acetylated chitooligosaccharide(NACOS) was prepared by N-acetylation of COS, and the anti-inflammatory activity of NACOS in macrophages were evaluated. The results indicated NACOS significantly suppressed the LPS-induced proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha) expression. Furthermore, the increased levels of reactive oxygen species (ROS) and nitric oxide (NO) were repressed by NACOS in a dose dependent manner. However, NACOS itself had no significant effect on the cell viability and cellular morphology. Signal transduction studies demonstrated that NACOS remarkably inhibited LPS-enhanced phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt. These findings provide a possible molecular mechanism by which NACOS inhibit LPS-induced inflammatory response in macrophages, and a basis for utilizing NACOS in pharmaceutical therapy against inflammation. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: RAW 264.7 CELLS ;  CHITOSAN OLIGOSACCHARIDES ;  IN-VITRO ;  ENDOTHELIAL-CELLS ;  MOLECULAR-WEIGHT ;  CHITIN ;  EXPRESSION ;  MICROGLIA ;  DISEASES ;  VIVO
语种: 英语
WOS记录号: WOS:000407696800119
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150006
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China

Recommended Citation:
Xu, Qingsong,Liu, Meisi,Liu, Qishun,et al. The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide[J]. CARBOHYDRATE POLYMERS,2017,174:1138-1143.
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