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The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide
Xu, Qingsong1,2; Liu, Meisi1; Liu, Qishun1; Wang, Wenxia1; Du, Yuguang3; Yin, Heng1
关键词N-acetylated Chitooligosaccharide Lipopolysaccharides Interleukin-6 Tumor Necrosis Factor-alpha Inflammation Pi3k/akt Pathway
刊名CARBOHYDRATE POLYMERS
2017-10-15
DOI10.1016/j.carbpol.2017.07.051
174页:1138-1143
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]RAW 264.7 CELLS ; CHITOSAN OLIGOSACCHARIDES ; IN-VITRO ; ENDOTHELIAL-CELLS ; MOLECULAR-WEIGHT ; CHITIN ; EXPRESSION ; MICROGLIA ; DISEASES ; VIVO
英文摘要Chitooligosaccharide (COS) has been shown to regulate many biological functions, such as antimicrobial effect and antitumor activity. In the present study, highly N-acetylated chitooligosaccharide(NACOS) was prepared by N-acetylation of COS, and the anti-inflammatory activity of NACOS in macrophages were evaluated. The results indicated NACOS significantly suppressed the LPS-induced proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha) expression. Furthermore, the increased levels of reactive oxygen species (ROS) and nitric oxide (NO) were repressed by NACOS in a dose dependent manner. However, NACOS itself had no significant effect on the cell viability and cellular morphology. Signal transduction studies demonstrated that NACOS remarkably inhibited LPS-enhanced phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt. These findings provide a possible molecular mechanism by which NACOS inhibit LPS-induced inflammatory response in macrophages, and a basis for utilizing NACOS in pharmaceutical therapy against inflammation. (C) 2017 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000407696800119
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/150006
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
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Xu, Qingsong,Liu, Meisi,Liu, Qishun,et al. The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide[J]. CARBOHYDRATE POLYMERS,2017,174:1138-1143.
APA Xu, Qingsong,Liu, Meisi,Liu, Qishun,Wang, Wenxia,Du, Yuguang,&Yin, Heng.(2017).The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide.CARBOHYDRATE POLYMERS,174,1138-1143.
MLA Xu, Qingsong,et al."The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide".CARBOHYDRATE POLYMERS 174(2017):1138-1143.
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