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题名: Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B
作者: Yang, Rui-xu1;  Hu, Chun-xiu2;  Sun, Wan-lu1;  Pan, Qin1;  Shen, Feng1;  Yang, Zhen3;  Su, Qing3;  Xu, Guo-wang2;  Fan, Jian-gao1
刊名: SCIENTIFIC REPORTS
发表日期: 2017-09-05
DOI: 10.1038/s41598-017-11278-x
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Chronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n = 23) and of biopsy-proven NAFLD (n = 42), CHB with NAFLD (n = 22) and without NAFLD (n = 17) were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. There were distinct serum lipidome between groups of NAFLD and CHB without NAFLD. Most of the neutral lipids and ceramide were elevated in the NAFLD group but were decreased in the CHB without NAFLD group. Plasmalogens were decreased in both groups. Triacylglycerols (TAGs) with lower carbon numbers and double bonds were increased in subjects with NASH. Serum monounsaturated TAG was a significant predictor of NASH (OR = 3.215; 95% CI 1.663-6.331) and positively correlated with histological activity (r = 0.501; P < 0.001). It showed good predictability for NASH in the NAFLD group [area under the receiver operating characteristic curves (AUROC) = 0.831] and was validated in the CHB group (AUROC = 0.833); this characteristic was superior to that of cytokeratin-18 and alanine transaminase. The increase in monounsaturated TAG might be a specific marker for NASH in both NAFLD and CHB patients.
关键词[WOS]: CONTROLLED ATTENUATION PARAMETER ;  INSULIN-RESISTANCE ;  METABOLIC SYNDROME ;  VIRUS INFECTION ;  STEATOSIS ;  FIBROSIS ;  PLASMALOGENS ;  PERFORMANCE ;  PROGRESSION ;  BIOMARKERS
语种: 英语
WOS记录号: WOS:000409309300105
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150013
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol,Ctr Fatty Liver, Shanghai 200092, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China

Recommended Citation:
Yang, Rui-xu,Hu, Chun-xiu,Sun, Wan-lu,et al. Serum Monounsaturated Triacylglycerol Predicts Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease and Chronic Hepatitis B[J]. SCIENTIFIC REPORTS,2017,7.
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