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题名: Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export
作者: Fan, Jing1;  Kuai, Bin1;  Wu, Guifen1;  Wu, Xudong2;  Chi, Binkai1;  Wang, Lantian1;  Wang, Ke1;  Shi, Zhubing1;  Zhang, Heng1;  Chen, She3;  He, Zhisong4;  Wang, Siyuan1;  Zhou, Zhaocai1;  Li, Guohui2;  Cheng, Hong1
关键词: ALYREF ;  ARS2 ;  hMTR4 ;  mRNA export ;  nuclear RNA degradation
刊名: EMBO JOURNAL
发表日期: 2017-10-02
DOI: 10.15252/embj.201696139
卷: 36, 期:19, 页:2870-2886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
英文摘要: The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome-mediated degradation of these RNAs requires its cofactor hMTR4. Significantly, hMTR4 plays a key role in specifically recruiting the exosome to its targets. Furthermore, we provide several lines of evidence indicating that hMTR4 executes this role by directly competing with the mRNA export adaptor ALYREF for associating with ARS2, a component of the cap-binding complex (CBC), and this competition is critical for determining whether an RNA is degraded or exported to the cytoplasm. Together, our results indicate that the competition between hMTR4 and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export.
关键词[WOS]: INTRONLESS MESSENGER-RNAS ;  CAP-BINDING COMPLEX ;  HUMAN TREX COMPLEX ;  SACCHAROMYCES-CEREVISIAE ;  POLY(A) POLYMERASE ;  TARGETING COMPLEX ;  MAMMALIAN-CELLS ;  QUALITY-CONTROL ;  II TRANSCRIPTS ;  RIBOSOMAL-RNA
语种: 英语
WOS记录号: WOS:000412115800007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150070
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Chinese Acad Sci, Chinese Acad Sci, State Key Lab Mol Biol,Shanghai Inst Biochem & Ce, Shanghai Key Lab Mol Androl,CAS Ctr Excellence Mo, Shanghai, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Dalian, Peoples R China
3.Natl Inst Biol Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China

Recommended Citation:
Fan, Jing,Kuai, Bin,Wu, Guifen,et al. Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export[J]. EMBO JOURNAL,2017,36(19):2870-2886.
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