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Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)
Lian, Ru1,2; Wu, Zhongping1; Lv, Xiaobao1; Rao, Yulan3; Li, Haiyang4; Li, Jinghua4; Wang, Rong1; Ni, Chunfang1; Zhang, Yurong1
关键词Drugs Of Abuse Dapp-ims Reduced Mobility Dart-tof-ms Rapid Screening
刊名FORENSIC SCIENCE INTERNATIONAL
2017-10-01
DOI10.1016/j.forsciint.2017.07.010
279页:268-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Medicine, Legal
研究领域[WOS]Legal Medicine
关键词[WOS]PSYCHOACTIVE SUBSTANCES ; SYNTHETIC CANNABINOIDS ; ACCUTOF-DART ; IDENTIFICATION ; VALIDATION ; ACCUTOF-DART(TM) ; QUANTIFICATION ; EXPLOSIVES ; DESORPTION ; CATHINONES
英文摘要Increasing in cases involving drugs of abuse leads to heavy burden for law enforcement agencies, exacerbating demand for rapid screening technique. In this study, atmospheric pressure ionization technologies including direct analysis in real time (DART) ion source coupled to a time-of-flight mass spectrometer (DART-TOF-MS) as well asdopant-assisted positive photoionization ion mobility spectrometry (DAPP-IMS) without radioactivity were utilized together as the powerful analytical tool for the rapid screening and identification of 53 abused drugs. The limits of detection (LOD) were 0.05-2 mu g/mL when using DART-TOF-MS and 0.02-2 mu g when using DAPP-IMS which could satisfy the actual requirement in forensic science laboratory. The advantages of this method included fast response, high-throughput potential, high specificity, and minimal sample preparation. A screening library of reduced mobility (K-0), accurate mass of informative precursor ion ([M+H](+)) and fragment ions was established respectively by employing a bench-top DAPP-IMS and TOF-MS in-source collision induced dissociation (CID) mode. Then the standardized screening procedure was developed with criteria for the confirmation of positive result. A total of 50 seized drug samples provided by local forensic laboratory we reanalyzed to testify the utility of the method. This study suggests that a method combing DART-TOF-MS and DAPP-IMS is promising for the rapid screening and identification of abused drugs with minimal sample preparation and absence of chromatography. (C) 2017 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000411904200038
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/150096
专题中国科学院大连化学物理研究所
作者单位1.Shanghai Inst Forens Sci, Shanghai Key Lab Crime Scene Evidence, Shanghai, Peoples R China
2.Shanghai Inst Pharmaceut Ind, China State Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China
3.Fudan Univ, Sch Basic Med Sci, Dept Forens Med, Ctr Forens Sci, Shanghai, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
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GB/T 7714
Lian, Ru,Wu, Zhongping,Lv, Xiaobao,et al. Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)[J]. FORENSIC SCIENCE INTERNATIONAL,2017,279:268-280.
APA Lian, Ru.,Wu, Zhongping.,Lv, Xiaobao.,Rao, Yulan.,Li, Haiyang.,...&Zhang, Yurong.(2017).Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS).FORENSIC SCIENCE INTERNATIONAL,279,268-280.
MLA Lian, Ru,et al."Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)".FORENSIC SCIENCE INTERNATIONAL 279(2017):268-280.
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