中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)
作者: Lian, Ru1, 2;  Wu, Zhongping1;  Lv, Xiaobao1;  Rao, Yulan3;  Li, Haiyang4;  Li, Jinghua4;  Wang, Rong1;  Ni, Chunfang1;  Zhang, Yurong1
关键词: Drugs of abuse ;  DAPP-IMS ;  Reduced mobility ;  DART-TOF-MS ;  Rapid screening
刊名: FORENSIC SCIENCE INTERNATIONAL
发表日期: 2017-10-01
DOI: 10.1016/j.forsciint.2017.07.010
卷: 279, 页:268-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Legal
研究领域[WOS]: Legal Medicine
英文摘要: Increasing in cases involving drugs of abuse leads to heavy burden for law enforcement agencies, exacerbating demand for rapid screening technique. In this study, atmospheric pressure ionization technologies including direct analysis in real time (DART) ion source coupled to a time-of-flight mass spectrometer (DART-TOF-MS) as well asdopant-assisted positive photoionization ion mobility spectrometry (DAPP-IMS) without radioactivity were utilized together as the powerful analytical tool for the rapid screening and identification of 53 abused drugs. The limits of detection (LOD) were 0.05-2 mu g/mL when using DART-TOF-MS and 0.02-2 mu g when using DAPP-IMS which could satisfy the actual requirement in forensic science laboratory. The advantages of this method included fast response, high-throughput potential, high specificity, and minimal sample preparation. A screening library of reduced mobility (K-0), accurate mass of informative precursor ion ([M+H](+)) and fragment ions was established respectively by employing a bench-top DAPP-IMS and TOF-MS in-source collision induced dissociation (CID) mode. Then the standardized screening procedure was developed with criteria for the confirmation of positive result. A total of 50 seized drug samples provided by local forensic laboratory we reanalyzed to testify the utility of the method. This study suggests that a method combing DART-TOF-MS and DAPP-IMS is promising for the rapid screening and identification of abused drugs with minimal sample preparation and absence of chromatography. (C) 2017 Elsevier B.V. All rights reserved.
关键词[WOS]: PSYCHOACTIVE SUBSTANCES ;  SYNTHETIC CANNABINOIDS ;  ACCUTOF-DART ;  IDENTIFICATION ;  VALIDATION ;  ACCUTOF-DART(TM) ;  QUANTIFICATION ;  EXPLOSIVES ;  DESORPTION ;  CATHINONES
语种: 英语
WOS记录号: WOS:000411904200038
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150096
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Shanghai Inst Forens Sci, Shanghai Key Lab Crime Scene Evidence, Shanghai, Peoples R China
2.Shanghai Inst Pharmaceut Ind, China State Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China
3.Fudan Univ, Sch Basic Med Sci, Dept Forens Med, Ctr Forens Sci, Shanghai, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Lian, Ru,Wu, Zhongping,Lv, Xiaobao,et al. Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)[J]. FORENSIC SCIENCE INTERNATIONAL,2017,279:268-280.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Lian, Ru]'s Articles
 [Wu, Zhongping]'s Articles
 [Lv, Xiaobao]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Lian, Ru]‘s Articles
 [Wu, Zhongping]‘s Articles
 [Lv, Xiaobao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace