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题名: Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid
作者: Zhang, Mingming3;  Zhang, Keyu1, 2;  Mehmood, Muhammad Aamer1, 2, 5;  Zhao, Zongbao Kent4;  Bai, Fengwu1, 2, 3;  Zhao, Xinqing1, 2
关键词: Saccharomyces cerevisiae ;  Acetic acid stress tolerance ;  Zinc sulfate ;  Ady2p ;  Ethanol production
刊名: BIORESOURCE TECHNOLOGY
发表日期: 2017-12-01
DOI: 10.1016/j.biortech.2017.05.191
卷: 245, 页:1461-1468
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Technology
类目[WOS]: Agricultural Engineering ;  Biotechnology & Applied Microbiology ;  Energy & Fuels
研究领域[WOS]: Agriculture ;  Biotechnology & Applied Microbiology ;  Energy & Fuels
英文摘要: The aim of this work was to study the effects of deleting acetate transporter gene ADY2 on growth and fermentation of Saccharomyces cerevisiae in the presence of inhibitors. Comparative transcriptome analysis revealed that three genes encoding plasma membrane carboxylic acid transporters, especially ADY2, were significantly downregulated under the zinc sulfate addition condition in the presence of acetic acid stress, and the deletion of ADY2 improved growth of S. cerevisiae under acetic acid, ethanol and hydrogen peroxide stresses. Consistently, a concomitant increase in ethanol production by 14.7% in the presence of 3.6 g/L acetic acid was observed in the ADY2 deletion mutant of S. cerevisiae BY4741. Decreased intracellular acetic acid, ROS accumulation, and plasma membrane permeability were observed in the ADY2 deletion mutant. These findings would be useful for developing robust yeast strains for efficient ethanol production. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: SELF-FLOCCULATING YEAST ;  PROGRAMMED CELL-DEATH ;  TRANSCRIPTOME ANALYSIS ;  LABORATORY EVOLUTION ;  IDENTIFICATION ;  ZINC ;  OVEREXPRESSION ;  FERMENTATION ;  RESISTANCE ;  SUPPLEMENTATION
语种: 英语
WOS记录号: WOS:000413038300021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150123
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
3.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
5.Govt Coll Univ Faisalabad, Dept Bioinformat & Biotechnol, Bioenergy Res Ctr, Faisalabad 38000, Pakistan

Recommended Citation:
Zhang, Mingming,Zhang, Keyu,Mehmood, Muhammad Aamer,et al. Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid[J]. BIORESOURCE TECHNOLOGY,2017,245:1461-1468.
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