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Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid
Zhang, Mingming3; Zhang, Keyu1,2; Mehmood, Muhammad Aamer1,2,5; Zhao, Zongbao Kent4; Bai, Fengwu1,2,3; Zhao, Xinqing1,2
关键词Saccharomyces Cerevisiae Acetic Acid Stress Tolerance Zinc Sulfate Ady2p Ethanol Production
刊名BIORESOURCE TECHNOLOGY
2017-12-01
DOI10.1016/j.biortech.2017.05.191
245页:1461-1468
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
类目[WOS]Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
研究领域[WOS]Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
关键词[WOS]SELF-FLOCCULATING YEAST ; PROGRAMMED CELL-DEATH ; TRANSCRIPTOME ANALYSIS ; LABORATORY EVOLUTION ; IDENTIFICATION ; ZINC ; OVEREXPRESSION ; FERMENTATION ; RESISTANCE ; SUPPLEMENTATION
英文摘要The aim of this work was to study the effects of deleting acetate transporter gene ADY2 on growth and fermentation of Saccharomyces cerevisiae in the presence of inhibitors. Comparative transcriptome analysis revealed that three genes encoding plasma membrane carboxylic acid transporters, especially ADY2, were significantly downregulated under the zinc sulfate addition condition in the presence of acetic acid stress, and the deletion of ADY2 improved growth of S. cerevisiae under acetic acid, ethanol and hydrogen peroxide stresses. Consistently, a concomitant increase in ethanol production by 14.7% in the presence of 3.6 g/L acetic acid was observed in the ADY2 deletion mutant of S. cerevisiae BY4741. Decreased intracellular acetic acid, ROS accumulation, and plasma membrane permeability were observed in the ADY2 deletion mutant. These findings would be useful for developing robust yeast strains for efficient ethanol production. (C) 2017 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000413038300021
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/150123
专题中国科学院大连化学物理研究所
作者单位1.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
3.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
5.Govt Coll Univ Faisalabad, Dept Bioinformat & Biotechnol, Bioenergy Res Ctr, Faisalabad 38000, Pakistan
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Zhang, Mingming,Zhang, Keyu,Mehmood, Muhammad Aamer,et al. Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid[J]. BIORESOURCE TECHNOLOGY,2017,245:1461-1468.
APA Zhang, Mingming,Zhang, Keyu,Mehmood, Muhammad Aamer,Zhao, Zongbao Kent,Bai, Fengwu,&Zhao, Xinqing.(2017).Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid.BIORESOURCE TECHNOLOGY,245,1461-1468.
MLA Zhang, Mingming,et al."Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid".BIORESOURCE TECHNOLOGY 245(2017):1461-1468.
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