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题名: Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization
作者: Rong, Jing-jing1;  Liang, Ming1;  Xuan, Feng-qi1;  Sun, Jing-yang1;  Zhao, Li-jun1;  Zheng, Hui-zhen2;  Tian, Xiao-xiang1;  Liu, Dan1;  Zhang, Quan-yu1;  Peng, Cheng-fei1;  Li, Fei1;  Wang, Xiao-zeng1;  Han, Ya-ling1;  Yu, Wei-ting2
关键词: Alginate ;  Thrombin ;  Microsphere ;  Transcatheter ;  Embolization ;  Hemostasis
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
发表日期: 2017-11-01
DOI: 10.1016/j.ijbiomac.2017.03.020
卷: 104, 页:1302-1312
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Applied ;  Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Polymer Science
英文摘要: Transcatheter arterial embolization (TAE) is the best non-laparotomy choice for solid visceral organs rupture and bleeding nowadays. In our previous study, a new biodegradable macromolecule material thrombin-loaded alginate-calcium microsphere (TACM) was prepared and its characteristics were investigated preliminarily. In this study, we further investigated the biocompatibility of TACMs, as well as physical characteristic, application method and effect of TACMs with thrombus (embolic agent). The in vivo results attested that TACMs were non-irritating and non-genotoxic with desired biocompatibility, although brought about a slight and temporary inflammation. Application research showed that the function of thrombin was inhibited by common contrast agents, and it was impracticable to add contrast agents in TACMs with thrombus for tracing under X-rays in TAE. Then, a novel delivery method was developed. In addition, stress resistance test indicated that the TACMs with thrombus was significantly stronger than single autologous thrombus, the optimized ratio of TACMs to whole blood was 2:3 for forming mixed thrombus. Finally, large animal experiment revealed that the novel embolic agent TACMs mixed thrombus was effective and safe in treating hemorrhage of solid abdominal viscera by TAE. (C) 2017 Published by Elsevier B.V.
关键词[WOS]: BLUNT SPLENIC TRAUMA ;  PROTEIN-C PATHWAY ;  POSTPARTUM HEMORRHAGE ;  CONTRAST AGENTS ;  INJURY ;  MANAGEMENT ;  CYTOTOXICITY ;  EXPERIENCE ;  EFFICACY ;  NECROSIS
语种: 英语
WOS记录号: WOS:000412959300145
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150128
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Gen Hosp Shenyang Mil Reg, Dept Cardiol, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China

Recommended Citation:
Rong, Jing-jing,Liang, Ming,Xuan, Feng-qi,et al. Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,104:1302-1312.
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