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Preparation and optimization of calcium pectate beads for cell encapsulation
Zhao, Shan1,2,3; Zhang, Ying2; Liu, Yang2; Yang, Fan4; Xiu, Zhilong1; Ma, Xiaojun4; Sun, Guangwei2
关键词Biomaterials Biomedical Applications Gels
刊名JOURNAL OF APPLIED POLYMER SCIENCE
2017-10-29
DOI10.1002/app.45685
135期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]LOW-METHOXYL-PECTIN ; EGG-BOX MODEL ; GEL BEADS ; BIOMEDICAL APPLICATIONS ; CA2+-PECTIN GELS ; DIVALENT-CATIONS ; DRUG-DELIVERY ; CITRUS PECTIN ; FT-IR ; ALGINATE
英文摘要A variety of natural polymers are considered suitable for cell entrapment. Pectin, a natural polysaccharide found in the cell walls of all higher terrestrial plants, presents great potential for cell encapsulation because of its ability to form gels. In this study, we investigated the influences of intrinsic and extrinsic factors on the formation and properties of calcium pectate (CP). Beads of CP prepared with 30-35% methyl esterification presented improved gel properties. The molecular weight (M-w), calcium content, and gel time did not significantly affect the gel properties. The gelling properties, sphericity factor (SF), and swelling ratio were significantly influenced by the degree of methyl esterification (DE) and pectin concentration. The DE (<40%), M-w, and calcium concentration had negative effects on the SFs of CP beads. Moreover, increases in the DE (<40%) and pectin concentration increased the swelling ratio. The C3A cells encapsulated in optimized CP beads maintained good viability and proliferation for up to 2 weeks. In conclusion, CP beads are a potential encapsulation material for cell immobilization and application in related fields. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45685.
语种英语
WOS记录号WOS:000411806400024
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/150149
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Zhao, Shan,Zhang, Ying,Liu, Yang,et al. Preparation and optimization of calcium pectate beads for cell encapsulation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2017,135(2).
APA Zhao, Shan.,Zhang, Ying.,Liu, Yang.,Yang, Fan.,Xiu, Zhilong.,...&Sun, Guangwei.(2017).Preparation and optimization of calcium pectate beads for cell encapsulation.JOURNAL OF APPLIED POLYMER SCIENCE,135(2).
MLA Zhao, Shan,et al."Preparation and optimization of calcium pectate beads for cell encapsulation".JOURNAL OF APPLIED POLYMER SCIENCE 135.2(2017).
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