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Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator
Chen, Mu-Wang1; Ji, Yue1; Wang, Jie1; Chen, Qing-An1; Shi, Lei1; Zhou, Yong-Gui1,2
Source PublicationORGANIC LETTERS
2017-09-15
DOI10.1021/acs.orglett.7b02502
Volume19Issue:18Pages:4988-4991
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordIRIDIUM-CATALYZED HYDROGENATION ; MULTIPLE STEREOGENIC CENTERS ; HALOGEN-BOND FORMATION ; ENANTIOSELECTIVE HYDROGENATION ; DIPHOSPHINE LIGANDS ; N-BROMOSUCCINIMIDE ; SALTS ; DERIVATIVES ; COMPLEXES ; BEARING
AbstractBy employing halogenide trichloroisocyanuric acid as a traceless activation reagent, a general iridium-catalyzed asymmetric hydrogenation of isoquinolines and pyridines is developed with up to 99% ee. This method avoids tedious steps of installation and removal of the activating groups. The mechanism studies indicated that hydrogen halide generated in situ acted as an activator of isoquinolines and pyridines.
Language英语
WOS IDWOS:000411304300072
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/150166
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
Recommended Citation
GB/T 7714
Chen, Mu-Wang,Ji, Yue,Wang, Jie,et al. Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator[J]. ORGANIC LETTERS,2017,19(18):4988-4991.
APA Chen, Mu-Wang,Ji, Yue,Wang, Jie,Chen, Qing-An,Shi, Lei,&Zhou, Yong-Gui.(2017).Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator.ORGANIC LETTERS,19(18),4988-4991.
MLA Chen, Mu-Wang,et al."Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in Situ as Activator".ORGANIC LETTERS 19.18(2017):4988-4991.
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