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Proteomic study provides new clues for complications of hemodialysis caused by dialysis membrane
Yang, Kaiguang1; Liu, Jianhui1,2; Sun, Jingdi3; Zhou, Yuan1; Zhao, Qun1; Li, Senwu1,2; Liu, Lukuan1,2; Zhang, Lihua1; Zhao, Jiuyang3; Zhang, Yukui1
KeywordProteomic Study Complications Of Hemodialysis Dialysis Membrane Ionic Liquid
Source PublicationSCIENCE BULLETIN
2017-09-30
DOI10.1016/j.scib.2017.08.026
Volume62Issue:18Pages:1251-1255
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordPOLYETHERSULFONE MEMBRANES ; PROTEIN ADSORPTION ; POLYSULFONE
AbstractThe complications of hemodialysis accompanied the hemodialysis and threaten the patients' life. Besides the loss of nutrient substance, such as amino acid and vitamin, we found new clues that the adsorbed proteins on common-used polysulfone-based dialysis membrane might be the reason according to the qualitative proteomic study by ionic liquid assisted sample preparation method. Our results indicated that the adsorbed proteins on the membrane were related with complement activation, blood coagulation, and leukocyte-related biological process. The quantitative proteome further demonstrated some significant changes of signal proteins in the post-dialysis plasma after the hemodialysis, such as beta-2-microglobulin and platelet factor-4, which would further verify these new clues. (C) 2017 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
Language英语
WOS IDWOS:000412131000008
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/150217
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yang, Kaiguang,Liu, Jianhui,Sun, Jingdi,et al. Proteomic study provides new clues for complications of hemodialysis caused by dialysis membrane[J]. SCIENCE BULLETIN,2017,62(18):1251-1255.
APA Yang, Kaiguang.,Liu, Jianhui.,Sun, Jingdi.,Zhou, Yuan.,Zhao, Qun.,...&Zhang, Yukui.(2017).Proteomic study provides new clues for complications of hemodialysis caused by dialysis membrane.SCIENCE BULLETIN,62(18),1251-1255.
MLA Yang, Kaiguang,et al."Proteomic study provides new clues for complications of hemodialysis caused by dialysis membrane".SCIENCE BULLETIN 62.18(2017):1251-1255.
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