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Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization
Rong, Jing-jing1; Liang, Ming1; Xuan, Feng-qi1; Sun, Jing-yang1; Zhao, Li-jun1; Zheng, Hui-zhen2; Tian, Xiao-xiang1; Liu, Dan1; Zhang, Quan-yu1; Peng, Cheng-fei1; Li, Fei1; Wang, Xiao-zeng1; Han, Ya-ling1; Yu, Wei-ting2
KeywordAlginate Thrombin Microsphere Transcatheter Embolization Hemostasis
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2017-11-01
DOI10.1016/j.ijbiomac.2017.03.020
Volume104Pages:1302-1312
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS KeywordBLUNT SPLENIC TRAUMA ; PROTEIN-C PATHWAY ; POSTPARTUM HEMORRHAGE ; CONTRAST AGENTS ; INJURY ; MANAGEMENT ; CYTOTOXICITY ; EXPERIENCE ; EFFICACY ; NECROSIS
AbstractTranscatheter arterial embolization (TAE) is the best non-laparotomy choice for solid visceral organs rupture and bleeding nowadays. In our previous study, a new biodegradable macromolecule material thrombin-loaded alginate-calcium microsphere (TACM) was prepared and its characteristics were investigated preliminarily. In this study, we further investigated the biocompatibility of TACMs, as well as physical characteristic, application method and effect of TACMs with thrombus (embolic agent). The in vivo results attested that TACMs were non-irritating and non-genotoxic with desired biocompatibility, although brought about a slight and temporary inflammation. Application research showed that the function of thrombin was inhibited by common contrast agents, and it was impracticable to add contrast agents in TACMs with thrombus for tracing under X-rays in TAE. Then, a novel delivery method was developed. In addition, stress resistance test indicated that the TACMs with thrombus was significantly stronger than single autologous thrombus, the optimized ratio of TACMs to whole blood was 2:3 for forming mixed thrombus. Finally, large animal experiment revealed that the novel embolic agent TACMs mixed thrombus was effective and safe in treating hemorrhage of solid abdominal viscera by TAE. (C) 2017 Published by Elsevier B.V.
Language英语
WOS IDWOS:000412959300145
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/150228
Collection中国科学院大连化学物理研究所
Affiliation1.Gen Hosp Shenyang Mil Reg, Dept Cardiol, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Rong, Jing-jing,Liang, Ming,Xuan, Feng-qi,et al. Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,104:1302-1312.
APA Rong, Jing-jing.,Liang, Ming.,Xuan, Feng-qi.,Sun, Jing-yang.,Zhao, Li-jun.,...&Yu, Wei-ting.(2017).Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,104,1302-1312.
MLA Rong, Jing-jing,et al."Thrombin-loaded alginate-calcium microspheres: A novel hemostatic embolic material for transcatheter arterial embolization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 104(2017):1302-1312.
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