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题名: An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry
作者: Zhang, Yiding1;  Ai, Wanpeng1;  Bai, Yu1;  Zhou, Yinglin1;  Wen, Luhong2;  Zhang, Xinxiang1;  Liu, Huwei1
关键词: Dielectric barrier discharge ionization ;  Capillary electrophoresis ;  Ambient mass spectrometry ;  Interface
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2016-12-01
DOI: 10.1007/s00216-016-9822-3
卷: 408, 期:30, 页:8655-8661
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
英文摘要: The online combination of capillary electrophoresis (CE) with mass spectrometry (MS) has long been desired for the capability of direct and simultaneous separation and detection with high efficiency, accuracy, and throughput. In this work, a novel CE-MS interface was developed, using dielectric barrier discharge ionization (DBDI). The interface employed a spray tip with a coaxial three-layer structure, into which the CE sample solution, the sheath liquid, and the nebulizing gas were introduced. The spray tip was put between the DBDI outlet and the MS inlet, thus the CE sample solution could be blended with the sheath liquid, then nebulized. The nebulized sample could be ionized by DBDI, and finally analyzed by MS. The key parameters of the interface were optimized. Then, proof-of-concept experiments separating and detecting the mixture of metronidazole and acetaminophen solutions were conducted. The results showed high separation efficiency, low time consumption, high reproducibility, and convenience in operation. In addition, the interface exhibited a high tolerance of non-volatile salts and surfactants, which would be widely used in CE analyses. All of these results demonstrated that the newly developed CE-DBDI-MS interface could be successfully used in CE-MS studies, and could be further utilized in multiple areas involving efficient separation and detection.
关键词[WOS]: SURFACE-PLASMON RESONANCE ;  ELECTROSPRAY-IONIZATION ;  ION-SOURCE ;  COMBINATION
语种: 英语
WOS记录号: WOS:000389605400009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/150439
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Inst Analyt Chem,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China
2.Ningbo Univ, Res Inst Adv Technol, Ningbo 315211, Zhejiang, Peoples R China

Recommended Citation:
Zhang, Yiding,Ai, Wanpeng,Bai, Yu,et al. An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016,408(30):8655-8661.
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