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An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry
Zhang, Yiding1; Ai, Wanpeng1; Bai, Yu1; Zhou, Yinglin1; Wen, Luhong2; Zhang, Xinxiang1; Liu, Huwei1
KeywordDielectric Barrier Discharge Ionization Capillary Electrophoresis Ambient Mass Spectrometry Interface
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
2016-12-01
DOI10.1007/s00216-016-9822-3
Volume408Issue:30Pages:8655-8661
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS KeywordSURFACE-PLASMON RESONANCE ; ELECTROSPRAY-IONIZATION ; ION-SOURCE ; COMBINATION
AbstractThe online combination of capillary electrophoresis (CE) with mass spectrometry (MS) has long been desired for the capability of direct and simultaneous separation and detection with high efficiency, accuracy, and throughput. In this work, a novel CE-MS interface was developed, using dielectric barrier discharge ionization (DBDI). The interface employed a spray tip with a coaxial three-layer structure, into which the CE sample solution, the sheath liquid, and the nebulizing gas were introduced. The spray tip was put between the DBDI outlet and the MS inlet, thus the CE sample solution could be blended with the sheath liquid, then nebulized. The nebulized sample could be ionized by DBDI, and finally analyzed by MS. The key parameters of the interface were optimized. Then, proof-of-concept experiments separating and detecting the mixture of metronidazole and acetaminophen solutions were conducted. The results showed high separation efficiency, low time consumption, high reproducibility, and convenience in operation. In addition, the interface exhibited a high tolerance of non-volatile salts and surfactants, which would be widely used in CE analyses. All of these results demonstrated that the newly developed CE-DBDI-MS interface could be successfully used in CE-MS studies, and could be further utilized in multiple areas involving efficient separation and detection.
Language英语
WOS IDWOS:000389605400009
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/150439
Collection中国科学院大连化学物理研究所
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Inst Analyt Chem,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China
2.Ningbo Univ, Res Inst Adv Technol, Ningbo 315211, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yiding,Ai, Wanpeng,Bai, Yu,et al. An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016,408(30):8655-8661.
APA Zhang, Yiding.,Ai, Wanpeng.,Bai, Yu.,Zhou, Yinglin.,Wen, Luhong.,...&Liu, Huwei.(2016).An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,408(30),8655-8661.
MLA Zhang, Yiding,et al."An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 408.30(2016):8655-8661.
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