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题名: Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching
作者: Xiong, Yuting1;  Jiang, Ge2;  Li, Minmin1;  Qing, Guangyan1;  Li, Xiuling2, 3;  Liang, Xinmiao2;  Sun, Taolei1, 4
刊名: SCIENTIFIC REPORTS
发表日期: 2017-01-13
DOI: 10.1038/srep40913
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's macroscopic property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose(0.11)), and reported carbohydrate-carbohydrate interaction (CCI)-promoted macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-glactose(0.11) further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable property, as well as high-performance glycopeptide enrichment materials.
关键词[WOS]: CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ;  TITANIUM-DIOXIDE CHROMATOGRAPHY ;  SELECTIVE ENRICHMENT ;  PHENYLBORONIC ACID ;  MASS-SPECTROMETRY ;  GLYCOPEPTIDE ENRICHMENT ;  MAGNETIC NANOPARTICLES ;  MESOPOROUS SILICA ;  GLYCOPROTEINS ;  SYSTEMS
语种: 英语
WOS记录号: WOS:000391931500001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151877
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China
4.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China

Recommended Citation:
Xiong, Yuting,Jiang, Ge,Li, Minmin,et al. Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching[J]. SCIENTIFIC REPORTS,2017,7.
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