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Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching
Xiong, Yuting1; Jiang, Ge2; Li, Minmin1; Qing, Guangyan1; Li, Xiuling2,3; Liang, Xinmiao2; Sun, Taolei1,4
Source PublicationSCIENTIFIC REPORTS
2017-01-13
DOI10.1038/srep40913
Volume7
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordCARBOHYDRATE-CARBOHYDRATE INTERACTIONS ; TITANIUM-DIOXIDE CHROMATOGRAPHY ; SELECTIVE ENRICHMENT ; PHENYLBORONIC ACID ; MASS-SPECTROMETRY ; GLYCOPEPTIDE ENRICHMENT ; MAGNETIC NANOPARTICLES ; MESOPOROUS SILICA ; GLYCOPROTEINS ; SYSTEMS
AbstractBiological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's macroscopic property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose(0.11)), and reported carbohydrate-carbohydrate interaction (CCI)-promoted macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-glactose(0.11) further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable property, as well as high-performance glycopeptide enrichment materials.
Language英语
WOS IDWOS:000391931500001
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151877
Collection中国科学院大连化学物理研究所
Affiliation1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China
4.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Xiong, Yuting,Jiang, Ge,Li, Minmin,et al. Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching[J]. SCIENTIFIC REPORTS,2017,7.
APA Xiong, Yuting.,Jiang, Ge.,Li, Minmin.,Qing, Guangyan.,Li, Xiuling.,...&Sun, Taolei.(2017).Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching.SCIENTIFIC REPORTS,7.
MLA Xiong, Yuting,et al."Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching".SCIENTIFIC REPORTS 7(2017).
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