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The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots
Yang, Jingai1; He, Xiwen1; Chen, Langxing1,2; Zhang, Yukui1,3
刊名ANALYTICAL METHODS
2016
DOI10.1039/c6ay02530g
8期:47页:8345-8351
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine ; Technology
类目[WOS]Chemistry, Analytical ; Food Science & Technology ; Spectroscopy
研究领域[WOS]Chemistry ; Food Science & Technology ; Spectroscopy
关键词[WOS]GRAPHENE QUANTUM DOTS ; CLASSICAL GALACTOSEMIA ; GLUCOSE ; PHOTOLUMINESCENCE ; NANOPARTICLES ; FABRICATION ; ENRICHMENT ; IMPAIRMENT ; TOLERANCE ; URINE
英文摘要In this paper, we presented a galactose biosensing system based on boronic acid functionalized carbon dots (APBA-Cdots) as the fluorescent probe. Carbon dots were directly synthesized by chemical oxidation with strong acids, and then they were linked to m-aminophenylboronic acid to form the APBA-Cdot fluorescent probe. Boronic acid groups on APBA-Cdot surfaces could covalently react with cis-diol units in galactose to form five- or six-membered cyclic esters. Compared with the close isomeric cousins of galactose such as fructose and glucose, galactose molecules possess more cis-conformational diol units in both pyranose and furanose forms, and as a result, they could selectively lead to the assembly and fluorescence quenching of APBA-Cdots. The fluorescence intensity linearly decreased with increase of galactose concentration in the range of 0 to 500 mu M, and a detection limit as low as 6.2 mu M was achieved. The proposed sensing system has been successfully used for the assay of galactose in human urine.
语种英语
WOS记录号WOS:000393100700013
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/151893
专题中国科学院大连化学物理研究所
作者单位1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Yang, Jingai,He, Xiwen,Chen, Langxing,et al. The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots[J]. ANALYTICAL METHODS,2016,8(47):8345-8351.
APA Yang, Jingai,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2016).The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots.ANALYTICAL METHODS,8(47),8345-8351.
MLA Yang, Jingai,et al."The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots".ANALYTICAL METHODS 8.47(2016):8345-8351.
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