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题名: Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites
作者: Tang, Chunlan1, 2;  Wang, Jialing1;  Yu, Jie1;  Wang, Li2;  Cheng, Mengchun2;  Cui, Wei1;  Zhao, Jinshun1;  Xiao, Hongbin3
关键词: N-6-(4-hydroxybenzyl) adenine riboside ;  Metabolism ;  Neuroprotection
刊名: PHYTOCHEMISTRY LETTERS
发表日期: 2017-06-01
DOI: 10.1016/j.phytol.2017.04.035
卷: 20, 页:146-150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: N-6-(4-hydroxybenzyl) adenine riboside (NHBA), isolated from Gastrodia elata Blume, has been demonstrated to show great pharmacological effects. The present study aimed to synthesize and identify the metabolites of NHBA, and to determine their neuroprotective potentials in vitro. After incubation with rat liver microsomes in the presence of NADPH, two metabolites were detected, which were further semisynthesized and identified as N-6-(4-hydroxylbenzyl) purine (NHBP) and N-6-(3,4-dihydroxylbenzyl) adenine riboside (ONHBA) by UPLC-QTOF-MS, H-1 NMR and C-13 NMR. Furthermore, the neuroprotective activities of NHBA and two metabolites were evaluated in SH-SY5Y cells. Our results demonstrated that NHBA substantially protected against H2O2-induced neuronal death in SH-SY5Y cells. Moreover, both ONHBA and NHBP could significantly prevent A beta oligomers-and H2O2-induced neuronal death in SH-SY5Y cells. These results suggested that NHBA and its metabolites, ONHBA and NHBP, might be suitable for the development of new drugs in the treatment of neurodegenerative diseases, including Alzheimer's disease in particular.
关键词[WOS]: GASTRODIA-ELATA BL ;  CELLS ;  PROTECTS
语种: 英语
WOS记录号: WOS:000405467600029
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151901
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Ningbo Univ, Zhejiang Prov Key Lab Pathol & Physiol Technol, Dept Prevent Med, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Tang, Chunlan,Wang, Jialing,Yu, Jie,et al. Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites[J]. PHYTOCHEMISTRY LETTERS,2017,20:146-150.
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