DICP OpenIR
Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites
Tang, Chunlan1,2; Wang, Jialing1; Yu, Jie1; Wang, Li2; Cheng, Mengchun2; Cui, Wei1; Zhao, Jinshun1; Xiao, Hongbin3
KeywordN-6-(4-hydroxybenzyl) Adenine Riboside Metabolism Neuroprotection
Source PublicationPHYTOCHEMISTRY LETTERS
2017-06-01
DOI10.1016/j.phytol.2017.04.035
Volume20Pages:146-150
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordGASTRODIA-ELATA BL ; CELLS ; PROTECTS
AbstractN-6-(4-hydroxybenzyl) adenine riboside (NHBA), isolated from Gastrodia elata Blume, has been demonstrated to show great pharmacological effects. The present study aimed to synthesize and identify the metabolites of NHBA, and to determine their neuroprotective potentials in vitro. After incubation with rat liver microsomes in the presence of NADPH, two metabolites were detected, which were further semisynthesized and identified as N-6-(4-hydroxylbenzyl) purine (NHBP) and N-6-(3,4-dihydroxylbenzyl) adenine riboside (ONHBA) by UPLC-QTOF-MS, H-1 NMR and C-13 NMR. Furthermore, the neuroprotective activities of NHBA and two metabolites were evaluated in SH-SY5Y cells. Our results demonstrated that NHBA substantially protected against H2O2-induced neuronal death in SH-SY5Y cells. Moreover, both ONHBA and NHBP could significantly prevent A beta oligomers-and H2O2-induced neuronal death in SH-SY5Y cells. These results suggested that NHBA and its metabolites, ONHBA and NHBP, might be suitable for the development of new drugs in the treatment of neurodegenerative diseases, including Alzheimer's disease in particular.
Language英语
WOS IDWOS:000405467600029
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151901
Collection中国科学院大连化学物理研究所
Affiliation1.Ningbo Univ, Zhejiang Prov Key Lab Pathol & Physiol Technol, Dept Prevent Med, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Tang, Chunlan,Wang, Jialing,Yu, Jie,et al. Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites[J]. PHYTOCHEMISTRY LETTERS,2017,20:146-150.
APA Tang, Chunlan.,Wang, Jialing.,Yu, Jie.,Wang, Li.,Cheng, Mengchun.,...&Xiao, Hongbin.(2017).Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites.PHYTOCHEMISTRY LETTERS,20,146-150.
MLA Tang, Chunlan,et al."Identification, characterization and in vitro neuroprotection of N-6-(4-hydroxybenzyl) adenine riboside and its metabolites".PHYTOCHEMISTRY LETTERS 20(2017):146-150.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tang, Chunlan]'s Articles
[Wang, Jialing]'s Articles
[Yu, Jie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tang, Chunlan]'s Articles
[Wang, Jialing]'s Articles
[Yu, Jie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tang, Chunlan]'s Articles
[Wang, Jialing]'s Articles
[Yu, Jie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.