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Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters
Liu, Chungang1; Wang, Juan1; Xu, Shiqi1; An, Shengshu1; Tang, Siying1; He, Jian2; Liu, Yang1; Lee, Robert J.1,3; Wang, Di1
KeywordPaecilomyces Tenuipes Chronic Unpredictable Mild Stress Antidepression Neurotransmitters
Source PublicationMOLECULAR MEDICINE REPORTS
2017-08-01
DOI10.3892/mmr.2017.6807
Volume16Issue:2Pages:2172-2178
Indexed BySCI ; SSCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS Research AreaOncology ; Research & Experimental Medicine
WOS KeywordBIOACTIVE COMPOUNDS ; DOPAMINE RELEASE ; MOUSE MODEL ; MICE ; SYSTEM ; ANTIDEPRESSANTS ; DISORDERS ; DISEASE ; AXIS ; EXPRESSION
AbstractThe medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)-induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant-like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS-induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant-like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression-model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment-resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters.
Language英语
WOS IDWOS:000405079300153
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151905
Collection中国科学院大连化学物理研究所
Affiliation1.Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Translat Med, Dalian 116023, Liaoning, Peoples R China
3.Ohio State Univ, Coll Pharm, Div Pharmaceut, 500 West 12th Ave, Columbus, OH 43201 USA
Recommended Citation
GB/T 7714
Liu, Chungang,Wang, Juan,Xu, Shiqi,et al. Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters[J]. MOLECULAR MEDICINE REPORTS,2017,16(2):2172-2178.
APA Liu, Chungang.,Wang, Juan.,Xu, Shiqi.,An, Shengshu.,Tang, Siying.,...&Wang, Di.(2017).Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters.MOLECULAR MEDICINE REPORTS,16(2),2172-2178.
MLA Liu, Chungang,et al."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters".MOLECULAR MEDICINE REPORTS 16.2(2017):2172-2178.
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