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题名: Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters
作者: Liu, Chungang1;  Wang, Juan1;  Xu, Shiqi1;  An, Shengshu1;  Tang, Siying1;  He, Jian2;  Liu, Yang1;  Lee, Robert J.1, 3;  Wang, Di1
关键词: Paecilomyces tenuipes ;  chronic unpredictable mild stress ;  antidepression ;  neurotransmitters
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2017-08-01
DOI: 10.3892/mmr.2017.6807
卷: 16, 期:2, 页:2172-2178
收录类别: SCI ;  SSCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology ;  Medicine, Research & Experimental
研究领域[WOS]: Oncology ;  Research & Experimental Medicine
英文摘要: The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)-induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant-like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS-induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant-like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression-model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment-resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters.
关键词[WOS]: BIOACTIVE COMPOUNDS ;  DOPAMINE RELEASE ;  MOUSE MODEL ;  MICE ;  SYSTEM ;  ANTIDEPRESSANTS ;  DISORDERS ;  DISEASE ;  AXIS ;  EXPRESSION
语种: 英语
WOS记录号: WOS:000405079300153
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151905
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Translat Med, Dalian 116023, Liaoning, Peoples R China
3.Ohio State Univ, Coll Pharm, Div Pharmaceut, 500 West 12th Ave, Columbus, OH 43201 USA

Recommended Citation:
Liu, Chungang,Wang, Juan,Xu, Shiqi,et al. Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters[J]. MOLECULAR MEDICINE REPORTS,2017,16(2):2172-2178.
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