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题名: Fluorescent Probes for Mitochondria! Reactive Oxygen Species in Biological Systems
作者: Lou Zhang-Rong1;  Li Peng1;  Han Ke-Li1
关键词: Fluorescent probe ;  Mitochondria ;  Reactive oxygen species ;  Small molecule ;  Living cells
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2017-06-14
DOI: 10.3866/PKU.WHXB201704284
卷: 33, 期:8, 页:1573-1588
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: In addition to being the energy powerhouse of the cell, mitochondria are an important source of reactive oxygen species (ROS) during the process of molecular oxygen metabolism. Mitochondrial ROS are closely associated with normal physiological functions as well as human diseases, and participate in cell signaling, nucleic acid and protein damage, and oxidative stress induction. However, the complicated interplay between mitochondrial ROS and the cellular pathological state has not been fully elucidated. It is expected that research on the mitochondrial ROS undertaking in the molecular pathogenesis of human diseases would benefit from development of efficient tools for the detection of these ROS. In recent years, an increasing number of fluorescent probes for mitochondrial ROS with high sensitivity and selectivity have been developed. Here, we present a review of the recent advances in small molecular fluorescent probes for selective detection of ROS inside the mitochondria. In this review, the design, synthesis, characteristics, and applications of the published fluorescent probes for mitochondrial ROS are discussed in detail.
关键词[WOS]: PHOTOINDUCED ELECTRON-TRANSFER ;  IMAGING HYDROGEN-PEROXIDE ;  LIVING CELLS ;  NITRIC-OXIDE ;  IN-VIVO ;  OXIDATIVE STRESS ;  TARGETING MITOCHONDRIA ;  SELECTIVE DETECTION ;  HYPOCHLOROUS ACID ;  LIVE CELLS
语种: 英语
WOS记录号: WOS:000405216100012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151910
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Lou Zhang-Rong,Li Peng,Han Ke-Li. Fluorescent Probes for Mitochondria! Reactive Oxygen Species in Biological Systems[J]. ACTA PHYSICO-CHIMICA SINICA,2017,33(8):1573-1588.
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