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题名: Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts
作者: Ji, Yue1, 2;  Feng, Guang-Shou1;  Chen, Mu-Wang1;  Shi, Lei1, 3;  Du, Haifeng3;  Zhou, Yong-Gui1
刊名: ORGANIC CHEMISTRY FRONTIERS
发表日期: 2017-06-01
DOI: 10.1039/c7qo00060j
卷: 4, 期:6, 页:1125-1129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: An enantioselective hydrogenation of cyclic iminium salts has been successfully realized by employing [Ir(COD)Cl](2) and chiral diphosphine ligands as catalyst, furnishing chiral N-alkyl tetrahydroisoquinolines and N-alkyl tetrahydro-beta-carbolines with up to 96% ee and 88% ee, respectively. The hydrogenation provides a direct, simple and efficient protocol toward chiral tertiary amines. Meanwhile, asymmetric hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity.
关键词[WOS]: BETA-CARBOLINE ALKALOIDS ;  N-H IMINES ;  ENANTIOSELECTIVE SYNTHESIS ;  HETEROAROMATIC-COMPOUNDS ;  PYRIDINIUM SALTS ;  PAENIBACILLUS-LACTIS ;  (R)-IMINE REDUCTASE ;  AQUEOUS-MEDIA ;  ANION-BINDING ;  TETRAHYDROISOQUINOLINE
语种: 英语
WOS记录号: WOS:000405862600033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151911
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

Recommended Citation:
Ji, Yue,Feng, Guang-Shou,Chen, Mu-Wang,et al. Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts[J]. ORGANIC CHEMISTRY FRONTIERS,2017,4(6):1125-1129.
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