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Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts
Ji, Yue1,2; Feng, Guang-Shou1; Chen, Mu-Wang1; Shi, Lei1,3; Du, Haifeng3; Zhou, Yong-Gui1
Source PublicationORGANIC CHEMISTRY FRONTIERS
2017-06-01
DOI10.1039/c7qo00060j
Volume4Issue:6Pages:1125-1129
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordBETA-CARBOLINE ALKALOIDS ; N-H IMINES ; ENANTIOSELECTIVE SYNTHESIS ; HETEROAROMATIC-COMPOUNDS ; PYRIDINIUM SALTS ; PAENIBACILLUS-LACTIS ; (R)-IMINE REDUCTASE ; AQUEOUS-MEDIA ; ANION-BINDING ; TETRAHYDROISOQUINOLINE
AbstractAn enantioselective hydrogenation of cyclic iminium salts has been successfully realized by employing [Ir(COD)Cl](2) and chiral diphosphine ligands as catalyst, furnishing chiral N-alkyl tetrahydroisoquinolines and N-alkyl tetrahydro-beta-carbolines with up to 96% ee and 88% ee, respectively. The hydrogenation provides a direct, simple and efficient protocol toward chiral tertiary amines. Meanwhile, asymmetric hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity.
Language英语
WOS IDWOS:000405862600033
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151911
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ji, Yue,Feng, Guang-Shou,Chen, Mu-Wang,et al. Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts[J]. ORGANIC CHEMISTRY FRONTIERS,2017,4(6):1125-1129.
APA Ji, Yue,Feng, Guang-Shou,Chen, Mu-Wang,Shi, Lei,Du, Haifeng,&Zhou, Yong-Gui.(2017).Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts.ORGANIC CHEMISTRY FRONTIERS,4(6),1125-1129.
MLA Ji, Yue,et al."Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts".ORGANIC CHEMISTRY FRONTIERS 4.6(2017):1125-1129.
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