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A Method to Access Symmetrical Tetrasubstituted Pyridines via Iodine and Ammonium Persulfate Mediated [2+2+1+1]-Cycloaddition Reaction
Liu, Weibing1; Tan, Hua1; Chen, Cui1; Pan, Yupeng2
KeywordSymmetrical Tetrasubstituted Pyridines [2+2+1]-cycloaddition -substituted Arones Alkynes n N-dimethyl Formamide (Dmf)
Source PublicationADVANCED SYNTHESIS & CATALYSIS
2017-05-02
DOI10.1002/adsc.201601225
Volume359Issue:9Pages:1594-1598
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS Research AreaChemistry
WOS KeywordCATALYZED CYCLIZATION ; DMF ; INHIBITORS ; KETONES ; DERIVATIVES
AbstractA novel metal-free [2+2+1+1]-cycloaddition method for rapid and productive preparation of symmetrical 2,3,5,6-tetrasubstituted pyridines has been developed from -substituted arones and N,N-dimethyl formamide (DMF) using iodine (I-2) and ammonium persulfate ((NH4)(2)S2O8) as mediators. In this process, both DMF and (NH4)(2)S2O8 play a dual role for the formation of pyridines. DMF acts as the reaction medium and the C4 source (the methyl group of DMF), while (NH4)(2)S2O8 serves as the oxidant and nitrogen resource. Notably, this transformation exhibited a broad substrate scope towards a wide variety of different arones to give the corresponding tetrasubstituted pyridines in moderate to excellent yields.
Language英语
WOS IDWOS:000400592100016
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151963
Collection中国科学院大连化学物理研究所
Affiliation1.Guangdong Univ Petrochem Technol, Coll Chem Engn, 2 Guandu Rd, Maoming 525000, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Liu, Weibing,Tan, Hua,Chen, Cui,et al. A Method to Access Symmetrical Tetrasubstituted Pyridines via Iodine and Ammonium Persulfate Mediated [2+2+1+1]-Cycloaddition Reaction[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(9):1594-1598.
APA Liu, Weibing,Tan, Hua,Chen, Cui,&Pan, Yupeng.(2017).A Method to Access Symmetrical Tetrasubstituted Pyridines via Iodine and Ammonium Persulfate Mediated [2+2+1+1]-Cycloaddition Reaction.ADVANCED SYNTHESIS & CATALYSIS,359(9),1594-1598.
MLA Liu, Weibing,et al."A Method to Access Symmetrical Tetrasubstituted Pyridines via Iodine and Ammonium Persulfate Mediated [2+2+1+1]-Cycloaddition Reaction".ADVANCED SYNTHESIS & CATALYSIS 359.9(2017):1594-1598.
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