DICP OpenIR
Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
Liang, Si-Cheng1,2,3; Ge, Guang-Bo1; Xia, Yang-Liu1; Dong, Pei-Pei4; Wang, Ping1; Qi, Xiao-Yi1,2; Tu, Cai-Xia2; Yang, Ling1
KeywordDaphnetin Comt Inhibitor 8-o-methyldaphnetin Ligand-protein Interaction Phase Ii Metabolite Structural Modification
Source PublicationXENOBIOTICA
2017-06-01
DOI10.1080/00498254.2016.1204567
Volume47Issue:6Pages:498-504
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS KeywordTANDEM MASS-SPECTROMETRY ; UDP-GLUCURONOSYLTRANSFERASES ; BIOACTIVITY ANALYSIS ; PHENOLIC-COMPOUNDS ; GLUCURONIDATION ; TOLCAPONE ; LIVER ; RAT ; COMT ; ENTACAPONE
Abstract1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously. Here the potential of daphnetin and its Phase II metabolites as inhibitors of COMT was investigated with human liver cytosol (HLC).
Language英语
WOS IDWOS:000399917500005
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/151986
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Liang, Si-Cheng,Ge, Guang-Bo,Xia, Yang-Liu,et al. Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites[J]. XENOBIOTICA,2017,47(6):498-504.
APA Liang, Si-Cheng.,Ge, Guang-Bo.,Xia, Yang-Liu.,Dong, Pei-Pei.,Wang, Ping.,...&Yang, Ling.(2017).Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites.XENOBIOTICA,47(6),498-504.
MLA Liang, Si-Cheng,et al."Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites".XENOBIOTICA 47.6(2017):498-504.
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