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Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
Liang, Si-Cheng1,2,3; Ge, Guang-Bo1; Xia, Yang-Liu1; Dong, Pei-Pei4; Wang, Ping1; Qi, Xiao-Yi1,2; Tu, Cai-Xia2; Yang, Ling1
关键词Daphnetin Comt Inhibitor 8-o-methyldaphnetin Ligand-protein Interaction Phase Ii Metabolite Structural Modification
刊名XENOBIOTICA
2017-06-01
DOI10.1080/00498254.2016.1204567
47期:6页:498-504
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]TANDEM MASS-SPECTROMETRY ; UDP-GLUCURONOSYLTRANSFERASES ; BIOACTIVITY ANALYSIS ; PHENOLIC-COMPOUNDS ; GLUCURONIDATION ; TOLCAPONE ; LIVER ; RAT ; COMT ; ENTACAPONE
英文摘要1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously. Here the potential of daphnetin and its Phase II metabolites as inhibitors of COMT was investigated with human liver cytosol (HLC).
语种英语
WOS记录号WOS:000399917500005
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/151986
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China
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GB/T 7714
Liang, Si-Cheng,Ge, Guang-Bo,Xia, Yang-Liu,et al. Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites[J]. XENOBIOTICA,2017,47(6):498-504.
APA Liang, Si-Cheng.,Ge, Guang-Bo.,Xia, Yang-Liu.,Dong, Pei-Pei.,Wang, Ping.,...&Yang, Ling.(2017).Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites.XENOBIOTICA,47(6),498-504.
MLA Liang, Si-Cheng,et al."Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites".XENOBIOTICA 47.6(2017):498-504.
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