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题名: Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
作者: Liang, Si-Cheng1, 2, 3;  Ge, Guang-Bo1;  Xia, Yang-Liu1;  Dong, Pei-Pei4;  Wang, Ping1;  Qi, Xiao-Yi1, 2;  Tu, Cai-Xia2;  Yang, Ling1
关键词: Daphnetin ;  COMT inhibitor ;  8-O-methyldaphnetin ;  ligand-protein interaction ;  Phase II metabolite ;  structural modification
刊名: XENOBIOTICA
发表日期: 2017-06-01
DOI: 10.1080/00498254.2016.1204567
卷: 47, 期:6, 页:498-504
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously. Here the potential of daphnetin and its Phase II metabolites as inhibitors of COMT was investigated with human liver cytosol (HLC).
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  UDP-GLUCURONOSYLTRANSFERASES ;  BIOACTIVITY ANALYSIS ;  PHENOLIC-COMPOUNDS ;  GLUCURONIDATION ;  TOLCAPONE ;  LIVER ;  RAT ;  COMT ;  ENTACAPONE
语种: 英语
WOS记录号: WOS:000399917500005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/151986
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China

Recommended Citation:
Liang, Si-Cheng,Ge, Guang-Bo,Xia, Yang-Liu,et al. Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites[J]. XENOBIOTICA,2017,47(6):498-504.
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