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题名: Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents
作者: Chen Chen1;  Wang Ping2;  Zou Liwei2;  Yang Ling2;  Fan Yiming2;  Hu Wenzhong1;  Ge Guangbo2
关键词: Hydroxylcoumarin ;  Antioxidant activity ;  Radical scavenging effect ;  Structure-activity relationship
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
发表日期: 2017-04-01
DOI: 10.1007/s40242-017-6411-8
卷: 33, 期:2, 页:194-199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: In this study, esculetin(1) was chosen as a lead compound and some structural modifications were designed to explore the antioxidant activities of esculetin derivatives. Meanwhile, a convenient method for selective methylation of catechol coumarins with different bases was developed. Furthermore, a few 5,7-dihydroxylcoumarins were synthesized and 7-hydroxylcoumarins were employed in order to explore the potential structure-antioxidant activity relationships. The antioxidant activities of these compounds were evaluated and compared with standard antioxidant Trolox by the 2,2'-diphenyl-1-picrylhydrazyl(DPPH) assay, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation(ABTS(+)) assay and ferric reducing antioxidant power(FRAP) assay. The results show that the catechol group is the key pharmacophore. Meanwhile, introducing electronegative groups at the C4 position of esculetin(1) may enhance the antioxidative capacity, while introducing a group containing nitrogen as a hydrogen bond acceptor at the C8 position may slightly reduce the antioxidative capacity. Among them, the most powerful antioxidants are compounds 5 and 7, which exhibit higher antioxidant activity than esculetin(1) in all assays.
关键词[WOS]: COUMARINS ;  POWER ;  SEEDS ;  ASSAY ;  FRAP
语种: 英语
WOS记录号: WOS:000399867100007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152000
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Minzu Univ, Coll Life Sci, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Chen Chen,Wang Ping,Zou Liwei,et al. Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(2):194-199.
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