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Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents
Chen Chen1; Wang Ping2; Zou Liwei2; Yang Ling2; Fan Yiming2; Hu Wenzhong1; Ge Guangbo2
KeywordHydroxylcoumarin Antioxidant Activity Radical Scavenging Effect Structure-activity Relationship
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
2017-04-01
DOI10.1007/s40242-017-6411-8
Volume33Issue:2Pages:194-199
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordCOUMARINS ; POWER ; SEEDS ; ASSAY ; FRAP
AbstractIn this study, esculetin(1) was chosen as a lead compound and some structural modifications were designed to explore the antioxidant activities of esculetin derivatives. Meanwhile, a convenient method for selective methylation of catechol coumarins with different bases was developed. Furthermore, a few 5,7-dihydroxylcoumarins were synthesized and 7-hydroxylcoumarins were employed in order to explore the potential structure-antioxidant activity relationships. The antioxidant activities of these compounds were evaluated and compared with standard antioxidant Trolox by the 2,2'-diphenyl-1-picrylhydrazyl(DPPH) assay, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation(ABTS(+)) assay and ferric reducing antioxidant power(FRAP) assay. The results show that the catechol group is the key pharmacophore. Meanwhile, introducing electronegative groups at the C4 position of esculetin(1) may enhance the antioxidative capacity, while introducing a group containing nitrogen as a hydrogen bond acceptor at the C8 position may slightly reduce the antioxidative capacity. Among them, the most powerful antioxidants are compounds 5 and 7, which exhibit higher antioxidant activity than esculetin(1) in all assays.
Language英语
WOS IDWOS:000399867100007
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152000
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Minzu Univ, Coll Life Sci, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Chen Chen,Wang Ping,Zou Liwei,et al. Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(2):194-199.
APA Chen Chen.,Wang Ping.,Zou Liwei.,Yang Ling.,Fan Yiming.,...&Ge Guangbo.(2017).Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(2),194-199.
MLA Chen Chen,et al."Synthesis and Biological Evaluation of Hydroxylcoumarin Derivatives as Antioxidant Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.2(2017):194-199.
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