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题名: Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach
作者: Jing, Yu1, 2, 3;  Wu, Xue2, 3;  Gao, Peng3, 4, 5;  Fang, Zhongze3, 6;  Wu, Jingjing3, 4;  Wang, Qingjun2, 3;  Li, Chen2, 3;  Zhu, Zhitu2, 3;  Cao, Yunfeng3, 4, 7
关键词: colorectal cancer ;  metabolomics ;  mass spectrometry
刊名: IUBMB LIFE
发表日期: 2017-05-01
DOI: 10.1002/iub.1617
卷: 69, 期:5, 页:347-354
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Cell Biology
英文摘要: Colorectal cancer (CRC) is the third leading causes of cancermortality, and the early-stage detection could significantly enhance survival rates. Cancer influences the important metabolic pathways and the changes in metabolite levels had been used in many studies as the potential biomarkers. This study is aimed at screening metabolite biomarkers with CRC diagnosis potentials. The direct infusion mass spectrometry (MS) metabolomic analysis based on dried blood spot was used to distinguish CRC from polyp. The target metabolites were composed of 23 amino acids and 26 acylcarnitines. The 21 metabolites in blood were selected via multivariate analysis. A regression model was established based on parameters C16, Arg, C4/C8, C5/C3, Val, Phe/Tyr, Ala, C4/C3. Tenfold cross validation (CV) method was used to test this model and showed sensitivity of 81.18% and specificity of 83.95%. The metabolomic analysis is a practicable method for CRC detection. The use of direct MS analysis in metabolite screening could be finished in several minutes and served as a higher-throughput method to distinguish CRC and polyps. (C) 2017
关键词[WOS]: BIOMARKER DISCOVERY ;  BREAST-CANCER ;  GROWTH ;  DISEASE
语种: 英语
WOS记录号: WOS:000399732000009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152014
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Jinzhou Med Univ, Jinzhou, Liaoning, Peoples R China
2.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou, Liaoning, Peoples R China
3.KLLTCM, Jinzhou, Liaoning, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
5.Dalian Sixth Peoples Hosp, Clin Lab, Dalian, Peoples R China
6.Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol, Tianjin, Peoples R China
7.Shanghai Inst Planned Parenthood Res, Key Lab Contracept & Devices Res NPFPC, Shanghai Engineer & Technol Res Ctr Reprod Hlth D, Shanghai, Peoples R China

Recommended Citation:
Jing, Yu,Wu, Xue,Gao, Peng,et al. Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach[J]. IUBMB LIFE,2017,69(5):347-354.
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