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Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach
Jing, Yu1,2,3; Wu, Xue2,3; Gao, Peng3,4,5; Fang, Zhongze3,6; Wu, Jingjing3,4; Wang, Qingjun2,3; Li, Chen2,3; Zhu, Zhitu2,3; Cao, Yunfeng3,4,7
KeywordColorectal Cancer Metabolomics Mass Spectrometry
Source PublicationIUBMB LIFE
2017-05-01
DOI10.1002/iub.1617
Volume69Issue:5Pages:347-354
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS KeywordBIOMARKER DISCOVERY ; BREAST-CANCER ; GROWTH ; DISEASE
AbstractColorectal cancer (CRC) is the third leading causes of cancermortality, and the early-stage detection could significantly enhance survival rates. Cancer influences the important metabolic pathways and the changes in metabolite levels had been used in many studies as the potential biomarkers. This study is aimed at screening metabolite biomarkers with CRC diagnosis potentials. The direct infusion mass spectrometry (MS) metabolomic analysis based on dried blood spot was used to distinguish CRC from polyp. The target metabolites were composed of 23 amino acids and 26 acylcarnitines. The 21 metabolites in blood were selected via multivariate analysis. A regression model was established based on parameters C16, Arg, C4/C8, C5/C3, Val, Phe/Tyr, Ala, C4/C3. Tenfold cross validation (CV) method was used to test this model and showed sensitivity of 81.18% and specificity of 83.95%. The metabolomic analysis is a practicable method for CRC detection. The use of direct MS analysis in metabolite screening could be finished in several minutes and served as a higher-throughput method to distinguish CRC and polyps. (C) 2017
Language英语
WOS IDWOS:000399732000009
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152014
Collection中国科学院大连化学物理研究所
Affiliation1.Jinzhou Med Univ, Jinzhou, Liaoning, Peoples R China
2.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou, Liaoning, Peoples R China
3.KLLTCM, Jinzhou, Liaoning, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
5.Dalian Sixth Peoples Hosp, Clin Lab, Dalian, Peoples R China
6.Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol, Tianjin, Peoples R China
7.Shanghai Inst Planned Parenthood Res, Key Lab Contracept & Devices Res NPFPC, Shanghai Engineer & Technol Res Ctr Reprod Hlth D, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Jing, Yu,Wu, Xue,Gao, Peng,et al. Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach[J]. IUBMB LIFE,2017,69(5):347-354.
APA Jing, Yu.,Wu, Xue.,Gao, Peng.,Fang, Zhongze.,Wu, Jingjing.,...&Cao, Yunfeng.(2017).Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach.IUBMB LIFE,69(5),347-354.
MLA Jing, Yu,et al."Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach".IUBMB LIFE 69.5(2017):347-354.
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