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题名: A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules
作者: Li, Xin1, 3;  Xu, Guiju1, 3;  Zhang, Hongyan1, 3;  Liu, Shengju1, 3;  Niu, Huan1, 3;  Peng, Jiaxi1, 3;  Wu, Jing2;  Wu, Ren'an1
关键词: Carbon nanospheres ;  Mass spectrometry ;  Surface assistant matrix ;  Biomolecules ;  Laser desorption/ionization
刊名: CARBON
发表日期: 2017-09-01
DOI: 10.1016/j.carbon.2017.05.099
卷: 121, 页:343-352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: In this work, a novel strategy for highly efficient detection of small molecules with a homogeneous carbon nanosphere film-spot (HCNFs) was carried out for the first time by negative surface-assisted laser desorption/ionization time-of-flight mass spectroscopy (SALDI-TOF MS). The HCNFs was fabricated by monolayer oxidized carbon nanospheres (OCS) self-assembling on laser desorption/ionization (LDI) target. With the HCNFs, no background interference and exclusive deprotonated ([M-H] ) peaks of analytes were obtained for a wide range of small biomolecules including fatty acids, amino acids, nucleobases, traditional Chinese medicines, and anti-cancer drugs in the negative SALDI-TOF MS. Comparing with other carbon-based matrices as well as the organic matrix, the monolayer OCS film exhibited various advantages including fewer interfering fragments, stronger signal intensities, and higher detection sensitivity. Moreover, with the improved spotting homogeneity of the HCNFs, "sweetspot" searching on LDI target was avoided and good reproducibility was obtained in the LDI-TOF MS analysis. This study is expanding the application of carbon nanospheres and providing a promising approach for rapid analysis of small molecules with none-interference and good reproducibility. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: IONIZATION MASS-SPECTROMETRY ;  MALDI-TOF MS ;  METAL-ORGANIC FRAMEWORKS ;  DESORPTION-IONIZATION ;  SMALL MOLECULES ;  GRAPHENE OXIDE ;  GOLD NANOPARTICLES ;  FATTY-ACIDS ;  MULTILAYER FILMS ;  FACILE SYNTHESIS
语种: 英语
WOS记录号: WOS:000405294400039
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152063
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Li, Xin,Xu, Guiju,Zhang, Hongyan,et al. A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules[J]. CARBON,2017,121:343-352.
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