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A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules
Li, Xin1,3; Xu, Guiju1,3; Zhang, Hongyan1,3; Liu, Shengju1,3; Niu, Huan1,3; Peng, Jiaxi1,3; Wu, Jing2; Wu, Ren'an1
KeywordCarbon Nanospheres Mass Spectrometry Surface Assistant Matrix Biomolecules Laser Desorption/ionization
Source PublicationCARBON
2017-09-01
DOI10.1016/j.carbon.2017.05.099
Volume121Pages:343-352
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Materials Science
WOS KeywordIONIZATION MASS-SPECTROMETRY ; MALDI-TOF MS ; METAL-ORGANIC FRAMEWORKS ; DESORPTION-IONIZATION ; SMALL MOLECULES ; GRAPHENE OXIDE ; GOLD NANOPARTICLES ; FATTY-ACIDS ; MULTILAYER FILMS ; FACILE SYNTHESIS
AbstractIn this work, a novel strategy for highly efficient detection of small molecules with a homogeneous carbon nanosphere film-spot (HCNFs) was carried out for the first time by negative surface-assisted laser desorption/ionization time-of-flight mass spectroscopy (SALDI-TOF MS). The HCNFs was fabricated by monolayer oxidized carbon nanospheres (OCS) self-assembling on laser desorption/ionization (LDI) target. With the HCNFs, no background interference and exclusive deprotonated ([M-H] ) peaks of analytes were obtained for a wide range of small biomolecules including fatty acids, amino acids, nucleobases, traditional Chinese medicines, and anti-cancer drugs in the negative SALDI-TOF MS. Comparing with other carbon-based matrices as well as the organic matrix, the monolayer OCS film exhibited various advantages including fewer interfering fragments, stronger signal intensities, and higher detection sensitivity. Moreover, with the improved spotting homogeneity of the HCNFs, "sweetspot" searching on LDI target was avoided and good reproducibility was obtained in the LDI-TOF MS analysis. This study is expanding the application of carbon nanospheres and providing a promising approach for rapid analysis of small molecules with none-interference and good reproducibility. (C) 2017 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000405294400039
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152063
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Xin,Xu, Guiju,Zhang, Hongyan,et al. A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules[J]. CARBON,2017,121:343-352.
APA Li, Xin.,Xu, Guiju.,Zhang, Hongyan.,Liu, Shengju.,Niu, Huan.,...&Wu, Ren'an.(2017).A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules.CARBON,121,343-352.
MLA Li, Xin,et al."A homogeneous carbon nanosphere film-spot: For highly efficient laser desorption/ionization of small biomolecules".CARBON 121(2017):343-352.
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