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题名: Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B
作者: Siridechakorn, Ittipon1, 2;  Yue, Zongwei1, 2;  Mittraphab, Yanisa3;  Lei, Xiaoguang1, 2;  Pudhom, Khanitha3
关键词: Endophytic fungi ;  Rhytidhysteron rufulum ;  Spirobisnaphthalene ;  Anti-cancer activity ;  Fungal cultivation
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2017-06-01
DOI: 10.1016/j.bmc.2017.02.054
卷: 25, 页:2878-2882
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Medicinal ;  Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ;  Pharmacology & Pharmacy ;  Chemistry
英文摘要: The cultivation of the mangrove-derived fungus Rhytidhysteron rufulum AS21B in acidic condition changed its secondary metabolite profile. Investigation of the culture broth extract led to the isolation and identification of two new spirobisnaphthalenes (1 and 2) together with eleven known compounds (313) from the crude extract of the fungus grown under an acidic condition as well as six known compounds (4, 10, 14-17) were isolated from the crude extract of the fungus grown under a neutral condition. Their structures were elucidated on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their cytotoxicity against two human cancer cell lines, Ramos lymphoma and drug resistant NSCLC H1975. Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
关键词[WOS]: EDENIA-GOMEZPOMPAE ;  INHIBITORS ;  PRODUCTS
语种: 英语
WOS记录号: WOS:000404693600008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152073
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn,S, Beijing 100871, Peoples R China
2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand

Recommended Citation:
Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,et al. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017,25:2878-2882.
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