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Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B
Siridechakorn, Ittipon1,2; Yue, Zongwei1,2; Mittraphab, Yanisa3; Lei, Xiaoguang1,2; Pudhom, Khanitha3
关键词Endophytic Fungi Rhytidhysteron Rufulum Spirobisnaphthalene Anti-cancer Activity Fungal Cultivation
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2017-06-01
DOI10.1016/j.bmc.2017.02.054
25页:2878-2882
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]EDENIA-GOMEZPOMPAE ; INHIBITORS ; PRODUCTS
英文摘要The cultivation of the mangrove-derived fungus Rhytidhysteron rufulum AS21B in acidic condition changed its secondary metabolite profile. Investigation of the culture broth extract led to the isolation and identification of two new spirobisnaphthalenes (1 and 2) together with eleven known compounds (313) from the crude extract of the fungus grown under an acidic condition as well as six known compounds (4, 10, 14-17) were isolated from the crude extract of the fungus grown under a neutral condition. Their structures were elucidated on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their cytotoxicity against two human cancer cell lines, Ramos lymphoma and drug resistant NSCLC H1975. Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000404693600008
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152073
专题中国科学院大连化学物理研究所
作者单位1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn,S, Beijing 100871, Peoples R China
2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand
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Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,et al. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017,25:2878-2882.
APA Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,Lei, Xiaoguang,&Pudhom, Khanitha.(2017).Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.BIOORGANIC & MEDICINAL CHEMISTRY,25,2878-2882.
MLA Siridechakorn, Ittipon,et al."Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B".BIOORGANIC & MEDICINAL CHEMISTRY 25(2017):2878-2882.
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