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Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B
Siridechakorn, Ittipon1,2; Yue, Zongwei1,2; Mittraphab, Yanisa3; Lei, Xiaoguang1,2; Pudhom, Khanitha3
KeywordEndophytic Fungi Rhytidhysteron Rufulum Spirobisnaphthalene Anti-cancer Activity Fungal Cultivation
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY
2017-06-01
DOI10.1016/j.bmc.2017.02.054
Volume25Pages:2878-2882
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS KeywordEDENIA-GOMEZPOMPAE ; INHIBITORS ; PRODUCTS
AbstractThe cultivation of the mangrove-derived fungus Rhytidhysteron rufulum AS21B in acidic condition changed its secondary metabolite profile. Investigation of the culture broth extract led to the isolation and identification of two new spirobisnaphthalenes (1 and 2) together with eleven known compounds (313) from the crude extract of the fungus grown under an acidic condition as well as six known compounds (4, 10, 14-17) were isolated from the crude extract of the fungus grown under a neutral condition. Their structures were elucidated on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their cytotoxicity against two human cancer cell lines, Ramos lymphoma and drug resistant NSCLC H1975. Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000404693600008
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152073
Collection中国科学院大连化学物理研究所
Affiliation1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn,S, Beijing 100871, Peoples R China
2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand
Recommended Citation
GB/T 7714
Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,et al. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017,25:2878-2882.
APA Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,Lei, Xiaoguang,&Pudhom, Khanitha.(2017).Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.BIOORGANIC & MEDICINAL CHEMISTRY,25,2878-2882.
MLA Siridechakorn, Ittipon,et al."Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B".BIOORGANIC & MEDICINAL CHEMISTRY 25(2017):2878-2882.
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