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题名: Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
作者: Liu, Ruixin1;  Hong, Jie1;  Xu, Xiaoqiang2, 3;  Feng, Qiang2, 4;  Zhang, Dongya2;  Gu, Yanyun1;  Shi, Juan1;  Zhao, Shaoqian1;  Liu, Wen1;  Wang, Xiaokai2, 3;  Xia, Huihua2, 5;  Liu, Zhipeng2;  Cui, Bin1, 6, 7;  Liang, Peiwen1;  Xi, Liuqing1;  Jin, Jiabin8;  Ying, Xiayang8;  Wang, Xiaolin9;  Zhao, Xinjie9;  Li, Wanyu1;  Jia, Huijue2, 5, 10;  Lan, Zhou2;  Li, Fengyu2;  Wang, Rui1;  Sun, Yingkai1;  Yang, Minglan1;  Shen, Yuxin1;  Jie, Zhuye2, 5;  Li, Junhua2, 5, 10;  Chen, Xiaomin2;  Zhong, Huanzi2, 5;  Xie, Hailiang2;  Zhang, Yifei1;  Gu, Weiqiong1;  Deng, Xiaxing8;  Shen, Baiyong8;  Xu, Xun2, 5;  Yang, Huanming2, 11;  Xu, Guowang9;  Bi, Yufang1;  Lai, Shenghan12;  Wang, Jian2, 11;  Qi, Lu13, 14;  Madsen, Lise2, 15, 16;  Wang, Jiqiu1;  Ning, Guang1, 6, 7;  Kristiansen, Karsten2, 5, 16;  Wang, Weiqing1
刊名: NATURE MEDICINE
发表日期: 2017-07-01
DOI: 10.1038/nm.4358
卷: 23, 页:859-+
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Cell Biology ;  Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ;  Cell Biology ;  Research & Experimental Medicine
英文摘要: Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
关键词[WOS]: Y GASTRIC BYPASS ;  DIET-INDUCED OBESITY ;  MONOSODIUM GLUTAMATE ;  BARIATRIC SURGERY ;  THETAIOTAOMICRON ;  RICHNESS ;  MARKERS ;  GLUCOSE ;  IMPACT ;  GENES
语种: 英语
WOS记录号: WOS:000405180100015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152082
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Sch Med, Natl Clin Res Ctr Endocrine & Metab Dis, State Key Lab Med Genomes,Ruijin Hosp, Shanghai, Peoples R China
2.BGI Shenzhen, Shenzhen, Peoples R China
3.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen, Peoples R China
4.BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen, Peoples R China
5.BGI Shenzhen, China Natl GeneBank, Shenzhen, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Pancreat Dis Ctr,Dept Gen Surg, Shanghai, Peoples R China
9.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
10.BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen, Peoples R China
11.James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China
12.Johns Hopkins Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA
13.Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA
14.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
15.Natl Inst Nutr & Seafood Res, Bergen, Norway
16.Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark

Recommended Citation:
Liu, Ruixin,Hong, Jie,Xu, Xiaoqiang,et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention[J]. NATURE MEDICINE,2017,23:859-+.
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