DICP OpenIR
Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging
Wang, Huihui1,2; Sun, Dongsheng1,2; Liao, Han1,2; Wang, Yanfang1,2; Zhao, Shan1,2; Zhang, Ying1; Lv, Guojun1; Ma, Xiaojun3; Liu, Yang1; Sun, Guangwei1
关键词Mri Nir Self-assembly Targeted Cellular Imaging Hyaluronic Acid Beta-cyclodextrin
刊名TALANTA
2017-08-15
DOI10.1016/j.talanta.2017.04.046
171页:8-15
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]HYALURONIC ACID-PACLITAXEL ; CONTRAST AGENT ; CANCER ; DELIVERY ; NANOPROBE ; CARCINOMA ; MICELLES ; MRI
英文摘要Multimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-beta-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments. The relaxivity and fluorescent properties of the NPs were also determined. HA-CD-GC NPs exhibited an enhanced relaxivity of 11.4 mM(-1)S(-1), which was three-fold higher than that of clinical Gds(3+)-chelated complex, for MRI imaging. Moreover, HA-CD-GC NPs displayed excellent fluorescence. In addition, HA-CD-GC NPs were internalized into tumor cells via HA-receptor CD44-mediated endocytosis. Therefore, the self-assembled HA-CD-GC NPs are effective targeted tumor cell imaging systems and have potential applications in cancer diagnosis and treatment.
语种英语
WOS记录号WOS:000403511500002
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152092
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Stem Cell Grp, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biotechnol, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Wang, Huihui,Sun, Dongsheng,Liao, Han,et al. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging[J]. TALANTA,2017,171:8-15.
APA Wang, Huihui.,Sun, Dongsheng.,Liao, Han.,Wang, Yanfang.,Zhao, Shan.,...&Sun, Guangwei.(2017).Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging.TALANTA,171,8-15.
MLA Wang, Huihui,et al."Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging".TALANTA 171(2017):8-15.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Huihui]的文章
[Sun, Dongsheng]的文章
[Liao, Han]的文章
百度学术
百度学术中相似的文章
[Wang, Huihui]的文章
[Sun, Dongsheng]的文章
[Liao, Han]的文章
必应学术
必应学术中相似的文章
[Wang, Huihui]的文章
[Sun, Dongsheng]的文章
[Liao, Han]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。