中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging
作者: Wang, Huihui1, 2;  Sun, Dongsheng1, 2;  Liao, Han1, 2;  Wang, Yanfang1, 2;  Zhao, Shan1, 2;  Zhang, Ying1;  Lv, Guojun1;  Ma, Xiaojun3;  Liu, Yang1;  Sun, Guangwei1
关键词: MRI ;  NIR ;  Self-assembly ;  Targeted cellular imaging ;  Hyaluronic acid ;  beta-cyclodextrin
刊名: TALANTA
发表日期: 2017-08-15
DOI: 10.1016/j.talanta.2017.04.046
卷: 171, 页:8-15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Multimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-beta-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments. The relaxivity and fluorescent properties of the NPs were also determined. HA-CD-GC NPs exhibited an enhanced relaxivity of 11.4 mM(-1)S(-1), which was three-fold higher than that of clinical Gds(3+)-chelated complex, for MRI imaging. Moreover, HA-CD-GC NPs displayed excellent fluorescence. In addition, HA-CD-GC NPs were internalized into tumor cells via HA-receptor CD44-mediated endocytosis. Therefore, the self-assembled HA-CD-GC NPs are effective targeted tumor cell imaging systems and have potential applications in cancer diagnosis and treatment.
关键词[WOS]: HYALURONIC ACID-PACLITAXEL ;  CONTRAST AGENT ;  CANCER ;  DELIVERY ;  NANOPROBE ;  CARCINOMA ;  MICELLES ;  MRI
语种: 英语
WOS记录号: WOS:000403511500002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152092
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Stem Cell Grp, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Wang, Huihui,Sun, Dongsheng,Liao, Han,et al. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging[J]. TALANTA,2017,171:8-15.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, Huihui]'s Articles
 [Sun, Dongsheng]'s Articles
 [Liao, Han]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, Huihui]‘s Articles
 [Sun, Dongsheng]‘s Articles
 [Liao, Han]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace