DICP OpenIR
Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging
Wang, Huihui1,2; Sun, Dongsheng1,2; Liao, Han1,2; Wang, Yanfang1,2; Zhao, Shan1,2; Zhang, Ying1; Lv, Guojun1; Ma, Xiaojun3; Liu, Yang1; Sun, Guangwei1
KeywordMri Nir Self-assembly Targeted Cellular Imaging Hyaluronic Acid Beta-cyclodextrin
Source PublicationTALANTA
2017-08-15
DOI10.1016/j.talanta.2017.04.046
Volume171Pages:8-15
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordHYALURONIC ACID-PACLITAXEL ; CONTRAST AGENT ; CANCER ; DELIVERY ; NANOPROBE ; CARCINOMA ; MICELLES ; MRI
AbstractMultimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-beta-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments. The relaxivity and fluorescent properties of the NPs were also determined. HA-CD-GC NPs exhibited an enhanced relaxivity of 11.4 mM(-1)S(-1), which was three-fold higher than that of clinical Gds(3+)-chelated complex, for MRI imaging. Moreover, HA-CD-GC NPs displayed excellent fluorescence. In addition, HA-CD-GC NPs were internalized into tumor cells via HA-receptor CD44-mediated endocytosis. Therefore, the self-assembled HA-CD-GC NPs are effective targeted tumor cell imaging systems and have potential applications in cancer diagnosis and treatment.
Language英语
WOS IDWOS:000403511500002
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152092
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Stem Cell Grp, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biotechnol, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wang, Huihui,Sun, Dongsheng,Liao, Han,et al. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging[J]. TALANTA,2017,171:8-15.
APA Wang, Huihui.,Sun, Dongsheng.,Liao, Han.,Wang, Yanfang.,Zhao, Shan.,...&Sun, Guangwei.(2017).Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging.TALANTA,171,8-15.
MLA Wang, Huihui,et al."Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging".TALANTA 171(2017):8-15.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Huihui]'s Articles
[Sun, Dongsheng]'s Articles
[Liao, Han]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Huihui]'s Articles
[Sun, Dongsheng]'s Articles
[Liao, Han]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Huihui]'s Articles
[Sun, Dongsheng]'s Articles
[Liao, Han]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.