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题名: The Nogo-B receptor promotes Ras plasma membrane localization and activation
作者: Zhao, B.1, 2, 3;  Hu, W.1, 2;  Kumar, S.2;  Gonyo, P.4;  Rana, U.1, 2;  Liu, Z.1, 2;  Wang, B.1, 2, 5;  Duong, W. Q.1, 2;  Yang, Z.6;  Williams, C. L.4;  Miao, Q. R.1, 2, 4
刊名: ONCOGENE
发表日期: 2017-06-15
DOI: 10.1038/onc.2016.484
卷: 36, 页:3406-3416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Oncology ;  Cell Biology ;  Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ;  Oncology ;  Cell Biology ;  Genetics & Heredity
英文摘要: The localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice. NgBR knockdown in human breast cancer cells reduces Ras membrane localization, inhibits epidermal growth factor (EGF)-stimulated Ras signaling and diminishes tumorigenesis of xenografts in nude mice. Our data demonstrate that NgBR is a unique receptor that promotes accumulation of prenylated Ras at the plasma membrane and promotes EGF pathways.
关键词[WOS]: UNDECAPRENYL PYROPHOSPHATE SYNTHASE ;  MAMMARY EPITHELIAL-CELLS ;  HUMAN BREAST-CANCER ;  H-RAS ;  K-RAS ;  MALIGNANT-TRANSFORMATION ;  DRUG-RESISTANCE ;  FAMILY PROTEINS ;  PDE-DELTA ;  IN-VITRO
语种: 英语
WOS记录号: WOS:000403340700005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152096
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Med Coll Wisconsin, Dept Surg, Childrens Res Inst, Div Pediat Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA
2.Med Coll Wisconsin, Dept Pathol, Childrens Res Inst, Div Pediat Pathol, Milwaukee, WI 53226 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci, Dalian, Liaoning, Peoples R China
4.Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
5.China Japan Friendship Hosp, Dept Pathol, Beijing, Peoples R China
6.Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI USA

Recommended Citation:
Zhao, B.,Hu, W.,Kumar, S.,et al. The Nogo-B receptor promotes Ras plasma membrane localization and activation[J]. ONCOGENE,2017,36:3406-3416.
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