DICP OpenIR
The Nogo-B receptor promotes Ras plasma membrane localization and activation
Zhao, B.1,2,3; Hu, W.1,2; Kumar, S.2; Gonyo, P.4; Rana, U.1,2; Liu, Z.1,2; Wang, B.1,2,5; Duong, W. Q.1,2; Yang, Z.6; Williams, C. L.4; Miao, Q. R.1,2,4
Source PublicationONCOGENE
2017-06-15
DOI10.1038/onc.2016.484
Volume36Pages:3406-3416
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS Research AreaBiochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
WOS KeywordUNDECAPRENYL PYROPHOSPHATE SYNTHASE ; MAMMARY EPITHELIAL-CELLS ; HUMAN BREAST-CANCER ; H-RAS ; K-RAS ; MALIGNANT-TRANSFORMATION ; DRUG-RESISTANCE ; FAMILY PROTEINS ; PDE-DELTA ; IN-VITRO
AbstractThe localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice. NgBR knockdown in human breast cancer cells reduces Ras membrane localization, inhibits epidermal growth factor (EGF)-stimulated Ras signaling and diminishes tumorigenesis of xenografts in nude mice. Our data demonstrate that NgBR is a unique receptor that promotes accumulation of prenylated Ras at the plasma membrane and promotes EGF pathways.
Language英语
WOS IDWOS:000403340700005
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152096
Collection中国科学院大连化学物理研究所
Affiliation1.Med Coll Wisconsin, Dept Surg, Childrens Res Inst, Div Pediat Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA
2.Med Coll Wisconsin, Dept Pathol, Childrens Res Inst, Div Pediat Pathol, Milwaukee, WI 53226 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci, Dalian, Liaoning, Peoples R China
4.Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
5.China Japan Friendship Hosp, Dept Pathol, Beijing, Peoples R China
6.Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI USA
Recommended Citation
GB/T 7714
Zhao, B.,Hu, W.,Kumar, S.,et al. The Nogo-B receptor promotes Ras plasma membrane localization and activation[J]. ONCOGENE,2017,36:3406-3416.
APA Zhao, B..,Hu, W..,Kumar, S..,Gonyo, P..,Rana, U..,...&Miao, Q. R..(2017).The Nogo-B receptor promotes Ras plasma membrane localization and activation.ONCOGENE,36,3406-3416.
MLA Zhao, B.,et al."The Nogo-B receptor promotes Ras plasma membrane localization and activation".ONCOGENE 36(2017):3406-3416.
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