DICP OpenIR
Chemical genomic analysis of GPR35 signaling
Hu, Heidi (Haibei)1,4; Deng, Huayun1; Ling, Shizhang1,5; Sun, Haiyan1,6; Kenakin, Terry2; Liang, Xinmiao3; Fang, Ye1
Source PublicationINTEGRATIVE BIOLOGY
2017-05-01
DOI10.1039/c7ib00005g
Volume9Pages:451-463
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectCell Biology
WOS Research AreaCell Biology
WOS KeywordPROTEIN-COUPLED RECEPTOR ; CONNECTIVITY MAP ; KYNURENIC ACID ; CELL-MIGRATION ; KINASE ; ACTIVATION ; EXPRESSION ; AGONISTS ; DISEASE ; LOCI
AbstractGPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases. However, not much is known about the signaling and functions of GPR35. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1 alpha, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. Collectively, our data suggest that GPR35 may play an important role in response to hypoxic stress and be a potential target for the treatment of inflammatory, cardiovascular, and neurological disorders.
Language英语
WOS IDWOS:000401911000007
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152257
Collection中国科学院大连化学物理研究所
Affiliation1.Corning Inc, Corning R&D Corp, Biochem Technol, Corning, NY 14831 USA
2.Univ N Carolina, Dept Pharmacol, Sch Med, Chapel Hill, NC 27599 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Liaoning, Peoples R China
4.Carilion Roanoke Mem Hosp, Quest Diagnost Lab, Carilion Clin Hlth Syst, Med Lab Sci,Jefferson Coll Hlth Sci, Roanoke, VA 24013 USA
5.Johns Hopkins Univ, Dept Med, Baltimore, MD USA
6.Arizona State Univ, Biodesign Inst, Lab Inflammat & Canc, Tempe, AZ USA
Recommended Citation
GB/T 7714
Hu, Heidi ,Deng, Huayun,Ling, Shizhang,et al. Chemical genomic analysis of GPR35 signaling[J]. INTEGRATIVE BIOLOGY,2017,9:451-463.
APA Hu, Heidi .,Deng, Huayun.,Ling, Shizhang.,Sun, Haiyan.,Kenakin, Terry.,...&Fang, Ye.(2017).Chemical genomic analysis of GPR35 signaling.INTEGRATIVE BIOLOGY,9,451-463.
MLA Hu, Heidi ,et al."Chemical genomic analysis of GPR35 signaling".INTEGRATIVE BIOLOGY 9(2017):451-463.
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