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题名: Chemical genomic analysis of GPR35 signaling
作者: Hu, Heidi (Haibei)1, 4;  Deng, Huayun1;  Ling, Shizhang1, 5;  Sun, Haiyan1, 6;  Kenakin, Terry2;  Liang, Xinmiao3;  Fang, Ye1
刊名: INTEGRATIVE BIOLOGY
发表日期: 2017-05-01
DOI: 10.1039/c7ib00005g
卷: 9, 页:451-463
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
英文摘要: GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases. However, not much is known about the signaling and functions of GPR35. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1 alpha, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. Collectively, our data suggest that GPR35 may play an important role in response to hypoxic stress and be a potential target for the treatment of inflammatory, cardiovascular, and neurological disorders.
关键词[WOS]: PROTEIN-COUPLED RECEPTOR ;  CONNECTIVITY MAP ;  KYNURENIC ACID ;  CELL-MIGRATION ;  KINASE ;  ACTIVATION ;  EXPRESSION ;  AGONISTS ;  DISEASE ;  LOCI
语种: 英语
WOS记录号: WOS:000401911000007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/152257
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Corning Inc, Corning R&D Corp, Biochem Technol, Corning, NY 14831 USA
2.Univ N Carolina, Dept Pharmacol, Sch Med, Chapel Hill, NC 27599 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Liaoning, Peoples R China
4.Carilion Roanoke Mem Hosp, Quest Diagnost Lab, Carilion Clin Hlth Syst, Med Lab Sci,Jefferson Coll Hlth Sci, Roanoke, VA 24013 USA
5.Johns Hopkins Univ, Dept Med, Baltimore, MD USA
6.Arizona State Univ, Biodesign Inst, Lab Inflammat & Canc, Tempe, AZ USA

Recommended Citation:
Hu, Heidi ,Deng, Huayun,Ling, Shizhang,et al. Chemical genomic analysis of GPR35 signaling[J]. INTEGRATIVE BIOLOGY,2017,9:451-463.
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