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Chemical genomic analysis of GPR35 signaling
Hu, Heidi (Haibei)1,4; Deng, Huayun1; Ling, Shizhang1,5; Sun, Haiyan1,6; Kenakin, Terry2; Liang, Xinmiao3; Fang, Ye1
刊名INTEGRATIVE BIOLOGY
2017-05-01
DOI10.1039/c7ib00005g
9页:451-463
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]PROTEIN-COUPLED RECEPTOR ; CONNECTIVITY MAP ; KYNURENIC ACID ; CELL-MIGRATION ; KINASE ; ACTIVATION ; EXPRESSION ; AGONISTS ; DISEASE ; LOCI
英文摘要GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases. However, not much is known about the signaling and functions of GPR35. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1 alpha, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. Collectively, our data suggest that GPR35 may play an important role in response to hypoxic stress and be a potential target for the treatment of inflammatory, cardiovascular, and neurological disorders.
语种英语
WOS记录号WOS:000401911000007
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152257
专题中国科学院大连化学物理研究所
作者单位1.Corning Inc, Corning R&D Corp, Biochem Technol, Corning, NY 14831 USA
2.Univ N Carolina, Dept Pharmacol, Sch Med, Chapel Hill, NC 27599 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Liaoning, Peoples R China
4.Carilion Roanoke Mem Hosp, Quest Diagnost Lab, Carilion Clin Hlth Syst, Med Lab Sci,Jefferson Coll Hlth Sci, Roanoke, VA 24013 USA
5.Johns Hopkins Univ, Dept Med, Baltimore, MD USA
6.Arizona State Univ, Biodesign Inst, Lab Inflammat & Canc, Tempe, AZ USA
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Hu, Heidi ,Deng, Huayun,Ling, Shizhang,et al. Chemical genomic analysis of GPR35 signaling[J]. INTEGRATIVE BIOLOGY,2017,9:451-463.
APA Hu, Heidi .,Deng, Huayun.,Ling, Shizhang.,Sun, Haiyan.,Kenakin, Terry.,...&Fang, Ye.(2017).Chemical genomic analysis of GPR35 signaling.INTEGRATIVE BIOLOGY,9,451-463.
MLA Hu, Heidi ,et al."Chemical genomic analysis of GPR35 signaling".INTEGRATIVE BIOLOGY 9(2017):451-463.
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