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Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion
Yu, Yang1,2; Jin, Yan1; Wang, Fangjun1; Yan, Jiaze1; Qi, Yanxia2; Ye, Mingliang1
KeywordAntler Velvet Protein Digestomics In-vitro Digestion Peptides Lc-ms/ms Bioactivity
Source PublicationFOOD RESEARCH INTERNATIONAL
2017-06-01
DOI10.1016/j.foodres.2017.04.002
Volume96Pages:182-190
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectFood Science & Technology
WOS Research AreaFood Science & Technology
WOS KeywordINDUCED MEMORY IMPAIRMENT ; PROLYL OLIGOPEPTIDASE ; CERVUS-ELAPHUS ; IN-VITRO ; ANTIOXIDANT ACTIVITY ; AQUEOUS EXTRACT ; DPP-IV ; PEPTIDES ; INHIBITORS ; POLYPEPTIDES
AbstractProteins are the most prominent bioactive component in deer antler velvet. The aim of the present study was to track the fate of protein of antler velvet by protein digestomics. The peptide profile identified by LC-MS/MS and the in vitro bioactivity of antler velvet aqueous extract (AAE) were investigated in simulated gastrointestinal digestion. A total of 23, 387 and 417 peptides in AAE, gastric and pancreatic digests were identified using LC-MS/MS, respectively. Collagens, the predominant proteins, released 34 peptides in gastric digests and 146 peptides in pancreatic digests. The gastric and pancreatic digests presented dipeptidyl peptidase IV (DPP-IV) and prolyl endopeptidase (PEP) inhibition activities. Four peptides from digests were proved to be DPP-IV and PEP inhibitory peptides. The results showed that the peptides released from antler velvet protein contributed to the bioactivity of antler velvet during digestion.
Language英语
WOS IDWOS:000402348300019
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/152276
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Ocean Univ, 52 Heishijiao St, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yu, Yang,Jin, Yan,Wang, Fangjun,et al. Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion[J]. FOOD RESEARCH INTERNATIONAL,2017,96:182-190.
APA Yu, Yang,Jin, Yan,Wang, Fangjun,Yan, Jiaze,Qi, Yanxia,&Ye, Mingliang.(2017).Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion.FOOD RESEARCH INTERNATIONAL,96,182-190.
MLA Yu, Yang,et al."Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion".FOOD RESEARCH INTERNATIONAL 96(2017):182-190.
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