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Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion
Yu, Yang1,2; Jin, Yan1; Wang, Fangjun1; Yan, Jiaze1; Qi, Yanxia2; Ye, Mingliang1
关键词Antler Velvet Protein Digestomics In-vitro Digestion Peptides Lc-ms/ms Bioactivity
刊名FOOD RESEARCH INTERNATIONAL
2017-06-01
DOI10.1016/j.foodres.2017.04.002
96页:182-190
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Food Science & Technology
研究领域[WOS]Food Science & Technology
关键词[WOS]INDUCED MEMORY IMPAIRMENT ; PROLYL OLIGOPEPTIDASE ; CERVUS-ELAPHUS ; IN-VITRO ; ANTIOXIDANT ACTIVITY ; AQUEOUS EXTRACT ; DPP-IV ; PEPTIDES ; INHIBITORS ; POLYPEPTIDES
英文摘要Proteins are the most prominent bioactive component in deer antler velvet. The aim of the present study was to track the fate of protein of antler velvet by protein digestomics. The peptide profile identified by LC-MS/MS and the in vitro bioactivity of antler velvet aqueous extract (AAE) were investigated in simulated gastrointestinal digestion. A total of 23, 387 and 417 peptides in AAE, gastric and pancreatic digests were identified using LC-MS/MS, respectively. Collagens, the predominant proteins, released 34 peptides in gastric digests and 146 peptides in pancreatic digests. The gastric and pancreatic digests presented dipeptidyl peptidase IV (DPP-IV) and prolyl endopeptidase (PEP) inhibition activities. Four peptides from digests were proved to be DPP-IV and PEP inhibitory peptides. The results showed that the peptides released from antler velvet protein contributed to the bioactivity of antler velvet during digestion.
语种英语
WOS记录号WOS:000402348300019
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/152276
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Ocean Univ, 52 Heishijiao St, Dalian 116023, Peoples R China
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GB/T 7714
Yu, Yang,Jin, Yan,Wang, Fangjun,et al. Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion[J]. FOOD RESEARCH INTERNATIONAL,2017,96:182-190.
APA Yu, Yang,Jin, Yan,Wang, Fangjun,Yan, Jiaze,Qi, Yanxia,&Ye, Mingliang.(2017).Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion.FOOD RESEARCH INTERNATIONAL,96,182-190.
MLA Yu, Yang,et al."Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion".FOOD RESEARCH INTERNATIONAL 96(2017):182-190.
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